7VYT
Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, T) | T-cell immunoreceptor with Ig and ITIM domains | polymer | 107 | 11643.9 | 2 | UniProt (Q495A1) Pfam (PF07686) | Homo sapiens (Human) | V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3 |
| 2 | B, E (B, H) | MG1131 heavy chain variable region | polymer | 122 | 13277.8 | 2 | Homo sapiens (Human) | ||
| 3 | D, F (L, C) | MG1131 light chain variable region | polymer | 135 | 13560.8 | 2 | Homo sapiens (Human) | ||
| 4 | G, H (H, C) | CITRATE ANION | non-polymer | 189.1 | 2 | Chemie (FLC) | |||
| 5 | I, J, K, L, M... (A, B, T, L, H...) | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 76965.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 378.2 | |
| All* | Total formula weight | 77343.3 |
