7VYT

Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, T	T-cell immunoreceptor with Ig and ITIM domains	polymer	107	11643.9	2	UniProt (Q495A1) Pfam (PF07686) In PDB	Homo sapiens (Human)	V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3
2	B, H	MG1131 heavy chain variable region	polymer	122	13277.8	2		Homo sapiens (Human)
3	L, C	MG1131 light chain variable region	polymer	135	13560.8	2		Homo sapiens (Human)
4	H, C	CITRATE ANION	non-polymer		189.1	2	Chemie (FLC)
5		water	water		18.0	388	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	76965.1
Non-Polymers*	Number of molecules	2
	Total formula weight	378.2
All*	Total formula weight	77343.3

*Water molecules are not included.