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2QBQ

Crystal structure of ptp1b-inhibitor complex

Summary for 2QBQ
Entry DOI10.2210/pdb2qbq/pdb
Related2AZR 2QBP 2QBR 2QBS
DescriptorTyrosine-protein phosphatase non-receptor type 1, 4-BROMO-3-(CARBOXYMETHOXY)-5-{3-[(3,3,5,5-TETRAMETHYLCYCLOHEXYL)AMINO]PHENYL}THIOPHENE-2-CARBOXYLIC ACID (3 entities in total)
Functional Keywordsprotein-inhibitor complex, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains1
Total formula weight35344.16
Authors
Xu, W. (deposition date: 2007-06-18, release date: 2008-03-18, Last modification date: 2024-02-21)
Primary citationWilson, D.P.,Wan, Z.K.,Xu, W.X.,Kirincich, S.J.,Follows, B.C.,Joseph-McCarthy, D.,Foreman, K.,Moretto, A.,Wu, J.,Zhu, M.,Binnun, E.,Zhang, Y.L.,Tam, M.,Erbe, D.V.,Tobin, J.,Xu, X.,Leung, L.,Shilling, A.,Tam, S.Y.,Mansour, T.S.,Lee, J.
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
J.Med.Chem., 50:4681-4698, 2007
Cited by
PubMed: 17705360
DOI: 10.1021/jm0702478
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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