1NDG
 
 | | Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme | | 分子名称: | ACETIC ACID, Lysozyme C, antibody kappa light chain, ... | | 著者 | Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J. | | 登録日 | 2002-12-09 | | 公開日 | 2003-06-03 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | X-ray snapshots of the maturation of an antibody response to a protein antigen
Nat.Struct.Biol., 10, 2003
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1NDM
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4N4G
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4N4I
 | | Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.3K36me3 | | 分子名称: | DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Peptide from Histone H3.3, ... | | 著者 | Li, Y, Ren, Y, Li, H. | | 登録日 | 2013-10-08 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | | 主引用文献 | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
Nature, 508, 2014
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4N4H
 | | Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.1K36me3 | | 分子名称: | DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Peptide from Histone H3.1, ... | | 著者 | Li, Y, Ren, Y, Li, H. | | 登録日 | 2013-10-08 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
Nature, 508, 2014
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1SMF
 | | Studies on an artificial trypsin inhibitor peptide derived from the mung bean inhibitor | | 分子名称: | BOWMAN-BIRK TYPE TRYPSIN INHIBITOR, CALCIUM ION, TRYPSIN | | 著者 | Huang, Q, Li, Y, Zhang, S, Liu, S, Tang, Y, Qi, C. | | 登録日 | 1992-10-24 | | 公開日 | 1994-07-31 | | 最終更新日 | 2017-06-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Studies on an artificial trypsin inhibitor peptide derived from the mung bean trypsin inhibitor: chemical synthesis, refolding, and crystallographic analysis of its complex with trypsin.
J.Biochem.(Tokyo), 116, 1994
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5J9S
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8XAB
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7P88
 | | Crystal structure of YTHDC1 with compound YLI_DC1_002 | | 分子名称: | 2-chloranyl-~{N}-methyl-9~{H}-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 | | 著者 | Bedi, R.K, Li, Y, Dolbois, A, Caflisch, A. | | 登録日 | 2021-07-21 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
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7P8F
 | | Crystal structure of YTHDC1 with compound YLI_DC1_008 | | 分子名称: | SULFATE ION, YTH domain-containing protein 1, ~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine | | 著者 | Bedi, R.K, Li, Y, Caflisch, A. | | 登録日 | 2021-07-21 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
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7P8A
 | | Crystal structure of YTHDC1 with compound YLI_DC1_003 | | 分子名称: | SULFATE ION, YTH domain-containing protein 1, ~{N},9-dimethylpurin-6-amine | | 著者 | Bedi, R.K, Li, Y, Dolbois, A, Caflisch, A. | | 登録日 | 2021-07-21 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
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7P8B
 | | Crystal structure of YTHDC1 with compound YLI_DC1_006 | | 分子名称: | 9-cyclopropyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 | | 著者 | Bedi, R.K, Li, Y, Dolbois, A, Caflisch, A. | | 登録日 | 2021-07-21 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
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7P87
 | | Crystal structure of YTHDC1 with compound YLI_DC1_001 | | 分子名称: | N-methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide, SULFATE ION, YTH domain-containing protein 1 | | 著者 | Bedi, R.K, Li, Y, Dolbois, A, Caflisch, A. | | 登録日 | 2021-07-21 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
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4WSI
 | | Crystal Structure of PALS1/Crb complex | | 分子名称: | MAGUK p55 subfamily member 5, Protein crumbs | | 著者 | Wei, Z, Li, Y, Zhang, M. | | 登録日 | 2014-10-28 | | 公開日 | 2014-11-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.
Proc.Natl.Acad.Sci.USA, 111, 2014
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6ZD7
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6ZD4
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6ZD3
 | | Crystal structure of YTHDC1 M438A mutant | | 分子名称: | DI(HYDROXYETHYL)ETHER, SULFATE ION, YTH domain containing 1 | | 著者 | Bedi, R.K, Li, Y, Caflisch, A. | | 登録日 | 2020-06-13 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
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6ZD5
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6ZDA
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6ZD8
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7BT6
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7BTB
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1TMM
 | | Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin | | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-HYDROXYMETHYLPTERIN, ACETATE ION, ... | | 著者 | Blaszczyk, J, Li, Y, Wu, Y, Shi, G, Ji, X, Yan, H. | | 登録日 | 2004-06-10 | | 公開日 | 2005-06-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies.
Biochemistry, 44, 2005
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6P05
 | | Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with compound 27 | | 分子名称: | Bromodomain-containing protein 4, GLYCEROL, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide | | 著者 | Ratia, K.M, Xiong, R, Li, Y, Zhao, J, Gutgesell, L.M, Shen, Z, Dye, K, Dubrovyskyii, O, Zhao, H, Huang, F, Tonetti, D.A, Thatcher, G.R. | | 登録日 | 2019-05-16 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
J.Med.Chem., 63, 2020
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6QPQ
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