6ZD5

Crystal structure of YTHDC1 S378A mutant complex with m6A

Summary for 6ZD5

Entry DOI	10.2210/pdb6zd5/pdb
Descriptor	YTH domain containing 1, SULFATE ION, N-methyladenosine, ... (4 entities in total)
Functional Keywords	ythdc1, m6a, complex, inhibitor, rna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	43137.30
Authors	Bedi, R.K.,Li, Y.,Caflisch, A. (deposition date: 2020-06-13, release date: 2021-01-13, Last modification date: 2024-01-24)
Primary citation	Li, Y.,Bedi, R.K.,Wiedmer, L.,Sun, X.,Huang, D.,Caflisch, A. Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17:1240-1249, 2021 Cited by PubMed: 33472367 DOI: 10.1021/acs.jctc.0c01136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation