1TMM
Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin
Summary for 1TMM
Entry DOI | 10.2210/pdb1tmm/pdb |
Related | 1CBK 1DY3 1EQ0 1EQM 1EX8 1F9H 1F9Y 1G4C 1HKA 1HQ2 1IM6 1KBR 1Q0N 1RB0 1RTZ 1RU1 1RU2 1TMJ |
Descriptor | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | pyrophosphokinase, pyrophosphoryl transfer, catalytic mechanism, folate, hppk, pterin, 6-hydroxymethyl-7, 8-dihydropterin, 6-hydroxymethylpterin, ternary complex, substrate specificity, product release, antimicrobial agent, drug design, transferase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 37747.79 |
Authors | |
Primary citation | Li, Y.,Blaszczyk, J.,Wu, Y.,Shi, G.,Ji, X.,Yan, H. Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies. Biochemistry, 44:8590-8599, 2005 Cited by PubMed: 15952765DOI: 10.1021/bi0503495 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
Download full validation report