Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 161 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | MG162 |
| A | APC171 |
| A | HOH404 |
| A | HOH408 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 162 |
| Chain | Residue |
| A | APC171 |
| A | HHR181 |
| A | HOH496 |
| A | ASP95 |
| A | ASP97 |
| A | MG161 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 163 |
| Chain | Residue |
| A | GLY26 |
| A | SER31 |
| A | HOH567 |
| A | HOH644 |
| A | HOH671 |
| A | HOH672 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 164 |
| Chain | Residue |
| A | LYS119 |
| A | PHE137 |
| A | PRO138 |
| A | ASP139 |
| A | HOH688 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 166 |
| Chain | Residue |
| A | HIS148 |
| A | THR149 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 167 |
| Chain | Residue |
| A | GLU30 |
| A | SER31 |
| A | HIS32 |
| A | HOH480 |
| A | HOH671 |
| A | HOH819 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 168 |
| Chain | Residue |
| A | LYS119 |
| A | GOL170 |
| A | HOH417 |
| A | HOH771 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 361 |
| Chain | Residue |
| B | ASP295 |
| B | ASP297 |
| B | MG362 |
| B | APC371 |
| B | HOH431 |
| B | HOH433 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 362 |
| Chain | Residue |
| B | ASP295 |
| B | ASP297 |
| B | MG361 |
| B | APC371 |
| B | HHR381 |
| B | HOH517 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 363 |
| Chain | Residue |
| B | LYS319 |
| B | PHE337 |
| B | ASP339 |
| B | HOH525 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 364 |
| Chain | Residue |
| A | VAL83 |
| A | ARG84 |
| A | HOH503 |
| A | HOH643 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 365 |
| Chain | Residue |
| A | ASN107 |
| B | PRO266 |
| B | GLU304 |
| B | HOH603 |
| B | HOH624 |
| B | HOH714 |
| site_id | BC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE APC A 171 |
| Chain | Residue |
| A | GLN74 |
| A | ARG82 |
| A | LYS85 |
| A | ALA86 |
| A | ARG92 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | ARG110 |
| A | LEU111 |
| A | THR112 |
| A | HIS115 |
| A | TYR116 |
| A | ARG121 |
| A | MG161 |
| A | MG162 |
| A | HHR181 |
| A | HOH404 |
| A | HOH408 |
| A | HOH435 |
| A | HOH440 |
| A | HOH460 |
| A | HOH496 |
| A | HOH575 |
| A | HOH584 |
| A | HOH601 |
| A | HOH627 |
| A | HOH805 |
| site_id | BC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HHR A 181 |
| Chain | Residue |
| A | HOH407 |
| A | HOH469 |
| A | HOH496 |
| A | HOH616 |
| A | THR42 |
| A | PRO43 |
| A | PRO44 |
| A | LEU45 |
| A | TYR53 |
| A | ASN55 |
| A | ASP95 |
| A | PHE123 |
| A | MG162 |
| A | APC171 |
| site_id | BC6 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE APC B 371 |
| Chain | Residue |
| B | LEU270 |
| B | GLN274 |
| B | ARG282 |
| B | LYS285 |
| B | ALA286 |
| B | ARG292 |
| B | ASP295 |
| B | ASP297 |
| B | ILE298 |
| B | ARG310 |
| B | LEU311 |
| B | THR312 |
| B | HIS315 |
| B | TYR316 |
| B | ARG321 |
| B | MG361 |
| B | MG362 |
| B | HHR381 |
| B | HOH431 |
| B | HOH433 |
| B | HOH436 |
| B | HOH449 |
| B | HOH471 |
| B | HOH473 |
| B | HOH507 |
| B | HOH517 |
| B | HOH576 |
| B | HOH605 |
| B | HOH670 |
| B | HOH889 |
| site_id | BC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE HHR B 381 |
| Chain | Residue |
| B | THR242 |
| B | PRO243 |
| B | LEU245 |
| B | TYR253 |
| B | ASN255 |
| B | ARG292 |
| B | ASP295 |
| B | PHE323 |
| B | MG362 |
| B | APC371 |
| B | HOH464 |
| B | HOH499 |
| B | HOH517 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 369 |
| Chain | Residue |
| B | GLN274 |
| B | LEU278 |
| B | LYS285 |
| B | HOH432 |
| B | HOH578 |
| B | HOH654 |
| B | HOH670 |
| B | HOH804 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 170 |
| Chain | Residue |
| A | THR112 |
| A | TYR116 |
| A | ACT168 |
| A | HOH409 |
| A | HOH920 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RaGPRtlDLDIM |
| Chain | Residue | Details |
| A | ARG88-MET99 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | ARG92 | |
| A | ARG82 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| B | ARG292 | |
| B | ARG282 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| A | VAL83 | electrostatic stabiliser, hydrogen bond donor |
| A | THR93 | electrostatic stabiliser, hydrogen bond donor |
| A | LEU96 | metal ligand |
| A | ILE98 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| B | VAL283 | electrostatic stabiliser, hydrogen bond donor |
| B | THR293 | electrostatic stabiliser, hydrogen bond donor |
| B | LEU296 | metal ligand |
| B | ILE298 | metal ligand |
