6P05
Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with compound 27
Summary for 6P05
Entry DOI | 10.2210/pdb6p05/pdb |
Descriptor | Bromodomain-containing protein 4, GLYCEROL, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide, ... (4 entities in total) |
Functional Keywords | inhibitor, brd4, bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15860.21 |
Authors | Ratia, K.M.,Xiong, R.,Li, Y.,Zhao, J.,Gutgesell, L.M.,Shen, Z.,Dye, K.,Dubrovyskyii, O.,Zhao, H.,Huang, F.,Tonetti, D.A.,Thatcher, G.R. (deposition date: 2019-05-16, release date: 2020-05-20, Last modification date: 2023-10-11) |
Primary citation | Li, Y.,Zhao, J.,Gutgesell, L.M.,Shen, Z.,Ratia, K.,Dye, K.,Dubrovskyi, O.,Zhao, H.,Huang, F.,Tonetti, D.A.,Thatcher, G.R.J.,Xiong, R. Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. J.Med.Chem., 63:7186-7210, 2020 Cited by PubMed: 32453591DOI: 10.1021/acs.jmedchem.0c00456 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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