5WP1
| Complex of ERK2 with 5,7-dihydroxychromone | 分子名称: | 5,7-dihydroxy-4H-1-benzopyran-4-one, BENZOIC ACID, Mitogen-activated protein kinase 1, ... | 著者 | Kurinov, I, Malakhova, M. | 登録日 | 2017-08-03 | 公開日 | 2018-08-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Multiple phytochemicals at low doses accumulatively inhibit one key protein in cancers To Be Published
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4ZXT
| Complex of ERK2 with catechol | 分子名称: | AMMONIUM ION, CATECHOL, Mitogen-activated protein kinase 1, ... | 著者 | Kurinov, I, Malakhova, M. | 登録日 | 2015-05-20 | 公開日 | 2016-05-25 | 最終更新日 | 2016-10-05 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer. Oncotarget, 7, 2016
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4N0S
| Complex of ERK2 with caffeic acid | 分子名称: | CAFFEIC ACID, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Kurinov, I, Malakhova, M. | 登録日 | 2013-10-02 | 公開日 | 2014-08-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7992 Å) | 主引用文献 | Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis. Cancer Prev Res (Phila), 7, 2014
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2OP2
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3G51
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3SA0
| Complex of ERK2 with norathyriol | 分子名称: | Mitogen-activated protein kinase 1, SULFATE ION, norathyriol | 著者 | Kurinov, I, Malakhova, M. | 登録日 | 2011-06-02 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5947 Å) | 主引用文献 | Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases. Cancer Res., 72, 2012
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3RTR
| A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases | 分子名称: | Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION | 著者 | Calabrese, M.F, Scott, D.C, Duda, D.M, Grace, C.R, Kurinov, I, Kriwacki, R.W, Schulman, B.A. | 登録日 | 2011-05-03 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases. Nat.Struct.Mol.Biol., 18, 2011
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8BW8
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3HYM
| Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure | 分子名称: | Anaphase-promoting complex subunit CDC26, Cell division cycle protein 16 homolog | 著者 | Wang, J, Dye, B.T, Rajashankar, K.R, Kurinov, I, Schulman, B.A. | 登録日 | 2009-06-22 | 公開日 | 2009-08-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Nat.Struct.Mol.Biol., 16, 2009
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6OCP
| Crystal structure of a human GABAB receptor peptide bound to KCTD16 T1 | 分子名称: | BTB/POZ domain-containing protein KCTD16, Gamma-aminobutyric acid type B receptor subunit 2 | 著者 | Zuo, H, Glaaser, I, Zhao, Y, Kurinov, I, Mosyak, L, Wang, H, Liu, J, Park, J, Frangaj, A, Sturchler, E, Zhou, M, McDonald, P, Geng, Y, Slesinger, P.A, Fan, Q.R. | 登録日 | 2019-03-25 | 公開日 | 2019-04-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for auxiliary subunit KCTD16 regulation of the GABABreceptor. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OCR
| Crystal structure of human KCTD16 T1 domain | 分子名称: | BTB/POZ domain-containing protein KCTD16 | 著者 | Zuo, H, Glaaser, I, Zhao, Y, Kurinov, I, Mosyak, L, Wang, H, Liu, J, Park, J, Frangaj, A, Sturchler, E, Zhou, M, McDonald, P, Geng, Y, Slesinger, P.A, Fan, Q.R. | 登録日 | 2019-03-25 | 公開日 | 2019-04-10 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structural basis for auxiliary subunit KCTD16 regulation of the GABABreceptor. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OCT
| Crystal structure of human KCTD16 T1 domain | 分子名称: | BTB/POZ domain-containing protein KCTD16 | 著者 | Zuo, H, Glaaser, I, Zhao, Y, Kurinov, I, Mosyak, L, Wang, H, Liu, J, Park, J, Frangaj, A, Sturchler, E, Zhou, M, McDonald, P, Geng, Y, Slesinger, P.A, Fan, Q.R. | 登録日 | 2019-03-25 | 公開日 | 2019-04-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for auxiliary subunit KCTD16 regulation of the GABABreceptor. Proc.Natl.Acad.Sci.USA, 116, 2019
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6UUO
| Crystal structure of BRAF kinase domain bound to the PROTAC P4B | 分子名称: | N-(3-{5-[(1-acetylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide, Serine/threonine-protein kinase B-raf | 著者 | Maisonneuve, P, Posternak, G, Kurinov, I, Sicheri, F. | 登録日 | 2019-10-30 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.288 Å) | 主引用文献 | Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat.Chem.Biol., 16, 2020
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5K5S
| Crystal structure of the active form of human calcium-sensing receptor extracellular domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ... | 著者 | Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R. | 登録日 | 2016-05-23 | 公開日 | 2016-08-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural mechanism of ligand activation in human calcium-sensing receptor. Elife, 5, 2016
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5K5T
| Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ... | 著者 | Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R. | 登録日 | 2016-05-23 | 公開日 | 2016-08-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural mechanism of ligand activation in human calcium-sensing receptor. Elife, 5, 2016
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4GSJ
| Crystal structure of Atg7 NTD K14A F16A D18A mutant | 分子名称: | CITRIC ACID, ISOPROPYL ALCOHOL, Ubiquitin-like modifier-activating enzyme ATG7 | 著者 | Kaiser, S.E, Mao, K, Taherbhoy, A.M, Yu, S, Olszewski, J.L, Duda, D.M, Kurinov, I, Deng, A, Fenn, T.D, Klionsky, D.J, Schulman, B.A. | 登録日 | 2012-08-27 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.695 Å) | 主引用文献 | Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat.Struct.Mol.Biol., 19, 2012
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4GSL
| Crystal structure of an Atg7-Atg3 crosslinked complex | 分子名称: | Autophagy-related protein 3, Ubiquitin-like modifier-activating enzyme ATG7, ZINC ION | 著者 | Kaiser, S.E, Mao, K, Taherbhoy, A.M, Yu, S, Olszewski, J.L, Duda, D.M, Kurinov, I, Deng, A, Fenn, T.D, Klionsky, D.J, Schulman, B.A. | 登録日 | 2012-08-27 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat.Struct.Mol.Biol., 19, 2012
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4GSK
| Crystal structure of an Atg7-Atg10 crosslinked complex | 分子名称: | Ubiquitin-like modifier-activating enzyme ATG7, Ubiquitin-like-conjugating enzyme ATG10, ZINC ION | 著者 | Kaiser, S.E, Mao, K, Taherbhoy, A.M, Yu, S, Olszewski, J.L, Duda, D.M, Kurinov, I, Deng, A, Fenn, T.D, Klionsky, D.J, Schulman, B.A. | 登録日 | 2012-08-27 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat.Struct.Mol.Biol., 19, 2012
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1YMR
| The study of reductive unfolding pathways of RNase A (Y92A mutant) | 分子名称: | Ribonuclease pancreatic | 著者 | Xu, G, Narayan, M, Kurinov, I, Ripoll, D.R, Welker, E, Khalili, M, Ealick, S.E, Scheraga, H.A. | 登録日 | 2005-01-21 | 公開日 | 2006-01-31 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A localized specific interaction alters the unfolding pathways of structural homologues. J.Am.Chem.Soc., 128, 2006
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1YMN
| The study of reductive unfolding pathways of RNase A (Y92L mutant) | 分子名称: | Ribonuclease pancreatic | 著者 | Xu, G, Narayan, M, Kurinov, I, Ripoll, D.R, Welker, E, Khalili, M, Ealick, S.E, Scheraga, H.A. | 登録日 | 2005-01-21 | 公開日 | 2006-01-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | A localized specific interaction alters the unfolding pathways of structural homologues. J.Am.Chem.Soc., 128, 2006
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1YMW
| The study of reductive unfolding pathways of RNase A (Y92G mutant) | 分子名称: | Ribonuclease pancreatic | 著者 | Xu, G, Narayan, M, Kurinov, I, Ripoll, D.R, Welker, E, Khalili, M, Ealick, S.E, Scheraga, H.A. | 登録日 | 2005-01-21 | 公開日 | 2006-01-31 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A localized specific interaction alters the unfolding pathways of structural homologues. J.Am.Chem.Soc., 128, 2006
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6NTD
| Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 12 of CRAF Kinase protein | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Maisonneuve, P, Kurinov, I, Wiechmann, S, Ernst, A, Sicheri, F. | 登録日 | 2019-01-28 | 公開日 | 2020-03-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J.Biol.Chem., 295, 2020
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6NSQ
| Crystal structure of BRAF kinase domain bound to the inhibitor 2l | 分子名称: | 5-[(4-amino-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine, Serine/threonine-protein kinase B-raf | 著者 | Maisonneuve, P, Kurinov, I, Assadieskandar, A, Yu, C, Zhang, C, Sicheri, F. | 登録日 | 2019-01-25 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases. Acs Med.Chem.Lett., 10, 2019
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6NTC
| Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 1 of CRAF Kinase protein | 分子名称: | GLYCEROL, GTPase HRas, MAGNESIUM ION, ... | 著者 | Maisonneuve, P, Kurinov, I, Wiechmann, S, Ernst, A, Sicheri, F. | 登録日 | 2019-01-28 | 公開日 | 2020-03-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J.Biol.Chem., 295, 2020
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5VYK
| Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1 | 分子名称: | Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf, GLYCEROL | 著者 | Maisonneuve, P, Kurinov, I, Marullo, S.A, Lavoie, H, Thevakumaran, N, Sahmi, M, Jin, T, Therrien, M, SIcheri, F. | 登録日 | 2017-05-25 | 公開日 | 2018-02-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | MEK drives BRAF activation through allosteric control of KSR proteins. Nature, 554, 2018
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