4XH2
 
 | | Crystal structure of human paxillin LD4 motif in complex with Fab fragment | | 分子名称: | ACETATE ION, ACETYL GROUP, Fab Heavy Chain, ... | | 著者 | Nocula-Lugowska, M, Lugowski, M, Salgia, R, Kossiakoff, A.A. | | 登録日 | 2015-01-04 | | 公開日 | 2015-07-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
J.Mol.Biol., 427, 2015
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4XMN
 | | Structure of the yeast coat nucleoporin complex, space group P212121 | | 分子名称: | Antibody 87 heavy chain, Antibody 87 light chain, Nucleoporin NUP120, ... | | 著者 | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | | 登録日 | 2015-01-14 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (7.6 Å) | | 主引用文献 | Nuclear pores. Architecture of the nuclear pore complex coat.
Science, 347, 2015
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4XWO
 | | Structure of Get3 bound to the transmembrane domain of Sec22 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, ... | | 著者 | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | | 登録日 | 2015-01-29 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
Science, 347, 2015
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4XMM
 | | Structure of the yeast coat nucleoporin complex, space group C2 | | 分子名称: | Antibody 57 heavy chain, Antibody 57 light chain, Nucleoporin NUP120, ... | | 著者 | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | | 登録日 | 2015-01-14 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (7.384 Å) | | 主引用文献 | Nuclear pores. Architecture of the nuclear pore complex coat.
Science, 347, 2015
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4XGZ
 | | Crystal structure of human paxillin LD2 motif in complex with Fab fragment | | 分子名称: | 1,2-ETHANEDIOL, FAB HEAVY CHAIN, FAB LIGHT CHAIN, ... | | 著者 | Nocula-Lugowska, M, Lugowski, M, Salgia, R, Kossiakoff, A.A. | | 登録日 | 2015-01-04 | | 公開日 | 2015-07-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
J.Mol.Biol., 427, 2015
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1TAW
 | | BOVINE TRYPSIN COMPLEXED TO APPI | | 分子名称: | CALCIUM ION, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, TRYPSIN | | 著者 | Hynes, T.R, Kossiakoff, A.A. | | 登録日 | 1996-12-19 | | 公開日 | 1997-06-24 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
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8T6I
 | | Structure of VHH-Fab complex with engineered Crystal Kappa region | | 分子名称: | Fab heavy chain, Fab light chain, GLYCEROL, ... | | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | | 登録日 | 2023-06-16 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
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8T58
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8T8I
 | | Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fab heavy chain, ... | | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | | 登録日 | 2023-06-22 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
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8T9Y
 | | Structure of VHH-Fab complex with engineered Elbow FNQIKG and Crystal Kappa regions | | 分子名称: | DI(HYDROXYETHYL)ETHER, Fab heavy chain, Fab light chain, ... | | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | | 登録日 | 2023-06-26 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
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8THE
 | | Cryo-EM structure of Pseudomonas aeruginosa TonB-dependent transporter PhuR in complex with synthetic antibody and heme | | 分子名称: | (2~{R},4~{R},5~{S},6~{S})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{R},4~{R},5~{S},6~{S})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{S})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Heme/hemoglobin uptake outer membrane receptor PhuR, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Knejski, P, Erramilli, S.K, Kossiakoff, A.A. | | 登録日 | 2023-07-15 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding.
Structure, 32, 2024
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8PG0
 | | Human OATP1B3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ... | | 著者 | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2023-06-17 | | 公開日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
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8PHW
 | | Human OATP1B1 | | 分子名称: | CHOLESTEROL HEMISUCCINATE, Fab18 (heavy chain, variable region), ... | | 著者 | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2023-06-20 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
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6RLX
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6SNI
 | | Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab | | 分子名称: | 6AG9-Fab heavy chain, 6AG9-Fab light chain, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | | 登録日 | 2019-08-24 | | 公開日 | 2020-03-11 | | 最終更新日 | 2020-04-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6.
Nature, 579, 2020
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6SNH
 | | Cryo-EM structure of yeast ALG6 in complex with 6AG9 Fab and Dol25-P-Glc | | 分子名称: | 6AG9 Fab heavy chain, 6AG9 Fab light chain, Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, ... | | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | | 登録日 | 2019-08-24 | | 公開日 | 2020-03-11 | | 最終更新日 | 2020-04-01 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6.
Nature, 579, 2020
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6U8C
 | | Crystal structure of an engineered ultra-high affinity Fab-Protein G complex | | 分子名称: | Antibody heavy chain Fab, Antibody light chain Fab, Protein G | | 著者 | Slezak, T, Filippova, E.V, Davydova, E.K, Kossiakoff, A.A. | | 登録日 | 2019-09-04 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
Protein Sci., 29, 2020
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6UKJ
 | | Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform | | 分子名称: | CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ... | | 著者 | Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F. | | 登録日 | 2019-10-05 | | 公開日 | 2019-12-04 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature, 576, 2019
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6USF
 | | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ... | | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | | 登録日 | 2019-10-26 | | 公開日 | 2020-04-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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6UR8
 | | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, ... | | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | | 登録日 | 2019-10-22 | | 公開日 | 2020-04-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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4JQI
 | | Structure of active beta-arrestin1 bound to a G protein-coupled receptor phosphopeptide | | 分子名称: | 1,2-ETHANEDIOL, Beta-arrestin-1, CHLORIDE ION, ... | | 著者 | Shukla, A.K, Manglik, A, Kruse, A.C, Xiao, K, Reis, R.I, Tseng, W.C, Staus, D.P, Hilger, D, Uysal, S, Huang, L.H, Paduch, M, Shukla, P.T, Koide, A, Koide, S, Weis, W.I, Kossiakoff, A.A, Kobilka, B.K, Lefkowitz, R.J. | | 登録日 | 2013-03-20 | | 公開日 | 2013-04-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Nature, 497, 2013
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1AAL
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1CA0
 | | BOVINE CHYMOTRYPSIN COMPLEXED TO APPI | | 分子名称: | BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR | | 著者 | Scheidig, A.J, Kossiakoff, A.A. | | 登録日 | 1997-01-23 | | 公開日 | 1997-07-23 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
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1CBW
 | | BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI | | 分子名称: | BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION | | 著者 | Hynes, T.R, Scheidig, A.J, Kossiakoff, A.A. | | 登録日 | 1996-12-22 | | 公開日 | 1997-07-23 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
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6B70
 | | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin | | 分子名称: | FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ... | | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | | 登録日 | 2017-10-03 | | 公開日 | 2017-12-27 | | 最終更新日 | 2021-04-28 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
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