1V79
 
 | | Crystal structures of adenosine deaminase complexed with potent inhibitors | | Descriptor: | 1-{(1R,2S)-1-[2-(2,3,-DICHLOROPHENYL)ETHYL]-2-HYDROXYPROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | | Authors: | Kinoshita, T. | | Deposit date: | 2003-12-14 | | Release date: | 2004-12-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
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7CRZ
 | | Crystal structure of human glucose transporter GLUT3 bound with C3361 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,3R,4S,5R,6R)-6-(hydroxymethyl)-4-undec-10-enoxy-oxane-2,3,5-triol, Solute carrier family 2, ... | | Authors: | Yuan, Y.Y, Zhang, S, Wang, N, Jiang, X, Yan, N. | | Deposit date: | 2020-08-14 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6RC9
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6RJ1
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5WRH
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1WXZ
 | | Crystal structure of adenosine deaminase ligated with a potent inhibitor | | Descriptor: | 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | | Authors: | Kinoshita, T. | | Deposit date: | 2005-02-02 | | Release date: | 2005-08-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism
J.Med.Chem., 48, 2005
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7W71
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7W6Z
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7W6X
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7W6Y
 | | Crystal structure of Kangiella koreensis RseP orthologue in complex with batimastat in space group P1 | | Descriptor: | 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, Anti sigma-E protein, RseA, ... | | Authors: | Imaizumi, Y, Takanuki, K, Nogi, T. | | Deposit date: | 2021-12-02 | | Release date: | 2022-09-07 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.
Sci Adv, 8, 2022
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7W70
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5H72
 | | Structure of the periplasmic domain of FliP | | Descriptor: | Flagellar biosynthetic protein FliP | | Authors: | Fukumura, T, Kawaguchi, T, Saijo-Hamano, Y, Namba, K, Minamino, T, Imada, K. | | Deposit date: | 2016-11-16 | | Release date: | 2017-08-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Assembly and stoichiometry of the core structure of the bacterial flagellar type III export gate complex
PLoS Biol., 15, 2017
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7CIK
 | | Structure of the 58-213 fragment of FliF | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Flagellar M-ring protein | | Authors: | Takekawa, T, Sakuma, M, Kojima, S, Homma, M, Imada, K. | | Deposit date: | 2020-07-07 | | Release date: | 2021-02-17 | | Last modified: | 2021-09-01 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Two Distinct Conformations in 34 FliF Subunits Generate Three Different Symmetries within the Flagellar MS-Ring.
Mbio, 12, 2021
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8H4O
 | | Crystal Structure of nucleotide-free Irgb6_T95D mutant | | Descriptor: | T-cell-specific guanine nucleotide triphosphate-binding protein 2 | | Authors: | Saijo-Hamano, Y, Okuma, H, Sakai, N, Kato, T, Imasaki, T, Nitta, R. | | Deposit date: | 2022-10-11 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I
To Be Published
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8H4M
 | | Crystal Structure of GTP-bound Irgb6_T95D mutant | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, T-cell-specific guanine nucleotide triphosphate-binding protein 2 | | Authors: | Saijo-Hamano, Y, Okuma, H, Sakai, N, Kato, T, Imasaki, T, Nitta, R. | | Deposit date: | 2022-10-10 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I
To Be Published
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7BWM
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7BY0
 | | The cryo-EM structure of CENP-A nucleosome in complex with the phosphorylated CENP-C | | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | Authors: | Ariyoshi, M, Makino, F, Fukagawa, T. | | Deposit date: | 2020-04-21 | | Release date: | 2021-02-10 | | Last modified: | 2021-03-10 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-EM structure of the CENP-A nucleosome in complex with phosphorylated CENP-C.
Embo J., 40, 2021
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7BXT
 | | The cryo-EM structure of CENP-A nucleosome in complex with CENP-C peptide and CENP-N N-terminal domain | | Descriptor: | CENP-C, DNA (145-mer), Histone H2A type 1-B/E, ... | | Authors: | Ariyoshi, M, Makino, F, Fukagawa, T. | | Deposit date: | 2020-04-20 | | Release date: | 2021-02-10 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM structure of the CENP-A nucleosome in complex with phosphorylated CENP-C.
Embo J., 40, 2021
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6M04
 | | Structure of the human homo-hexameric LRRC8D channel at 4.36 Angstroms | | Descriptor: | Volume-regulated anion channel subunit LRRC8D | | Authors: | Nakamura, R, Kasuya, G, Yokoyama, T, Shirouzu, M, Ishitani, R, Nureki, O. | | Deposit date: | 2020-02-20 | | Release date: | 2020-06-17 | | Method: | ELECTRON MICROSCOPY (4.36 Å) | | Cite: | Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.
Commun Biol, 3, 2020
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2E1W
 | | Crystal structure of adenosine deaminase complexed with potent inhibitors | | Descriptor: | 1-{(1R,2S)-2-HYDROXY-1-[2-(1-NAPHTHYL)ETHYL]PROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | | Authors: | Kinoshita, T. | | Deposit date: | 2006-10-30 | | Release date: | 2006-11-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors
J.Med.Chem., 47, 2004
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6M2L
 | | Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with C3361 | | Descriptor: | (2S,3R,4S,5R,6R)-6-(hydroxymethyl)-4-undec-10-enoxy-oxane-2,3,5-triol, Hexose transporter 1 | | Authors: | Jiang, X, Yuan, Y.Y, Zhang, S, Wang, N, Yan, C.Y, Yan, N. | | Deposit date: | 2020-02-27 | | Release date: | 2020-09-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.
Cell, 183, 2020
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6M20
 | | Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with glucose | | Descriptor: | Hexose transporter 1, beta-D-glucopyranose, nonyl beta-D-glucopyranoside | | Authors: | Jiang, X, Yuan, Y.Y, Zhang, S, Wang, N, Yan, C.Y, Yan, N. | | Deposit date: | 2020-02-26 | | Release date: | 2020-09-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.
Cell, 183, 2020
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2MME
 | | Hybrid structure of the Shigella flexneri MxiH Type three secretion system needle | | Descriptor: | MxiH | | Authors: | Demers, J.P, Habenstein, B, Loquet, A, Vasa, S.K, Becker, S, Baker, D, Lange, A, Sgourakis, N.G. | | Deposit date: | 2014-03-14 | | Release date: | 2014-10-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (7.7 Å), SOLID-STATE NMR | | Cite: | High-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy.
Nat Commun, 5, 2014
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3WBN
 | | Crystal structure of MATE in complex with MaL6 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MaL6, Putative uncharacterized protein | | Authors: | Tanaka, Y, Ishitani, R, Nureki, O. | | Deposit date: | 2013-05-20 | | Release date: | 2013-06-12 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.
Nature, 496, 2013
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6GF6
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