6BJ2
| TCR589 in complex with HIV(Pol448-456)/HLA-B35 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | 著者 | Jude, K.M, Sibener, L.V, Garcia, K.C. | 登録日 | 2017-11-03 | 公開日 | 2018-07-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174, 2018
|
|
8DA7
| |
8DA8
| |
8DA9
| Coevolved affibody-Z domain pair LL2.c3 | 分子名称: | Affibody LL2.FIIV, GLYCEROL, Immunoglobulin G-binding protein A, ... | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | 登録日 | 2022-06-13 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
|
|
8DAC
| |
8DA3
| Coevolved affibody-Z domain pair LL1.c1 | 分子名称: | Affibody LL1.FILF, Immunoglobulin G-binding protein A, MALONATE ION, ... | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | 登録日 | 2022-06-13 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
|
|
8DA4
| Coevolved affibody-Z domain pair LL1.c2 | 分子名称: | Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ... | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | 登録日 | 2022-06-13 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
|
|
8DAB
| |
8DA6
| |
8DA5
| |
8DAA
| |
8DZ8
| |
8FFE
| Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | 分子名称: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | 著者 | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | 登録日 | 2022-12-08 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-22 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
5UTZ
| Human IL-2/Fab complex | 分子名称: | Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... | 著者 | Jude, K.M, Garcia, K.C. | 登録日 | 2017-02-15 | 公開日 | 2018-07-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.747 Å) | 主引用文献 | A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat. Med., 24, 2018
|
|
5WB1
| |
5WB2
| US28 bound to engineered chemokine CX3CL1.35 and nanobodies | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ... | 著者 | Jude, K.M, Burg, J.S, Tsutsumi, N, Miles, T.F, Garcia, K.C. | 登録日 | 2017-06-27 | 公開日 | 2018-06-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. Elife, 7, 2018
|
|
7RA9
| Designed StabIL-2 seq1 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | 登録日 | 2021-06-30 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7RAA
| Designed StabIL-2 seq15 | 分子名称: | Interleukin-2, MAGNESIUM ION | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | 登録日 | 2021-06-30 | 公開日 | 2022-03-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8VRW
| Cryo-EM structure of human invariant chain in complex with HLA-DR15 | 分子名称: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... | 著者 | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | 登録日 | 2024-01-22 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8VSP
| Cryo-EM structure of human invariant chain in complex with HLA-DQ | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, ... | 著者 | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | 登録日 | 2024-01-24 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
3CYU
| Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon | 分子名称: | Carbonic anhydrase 2, MoMo-2-[4-(2-(4-(methoxy)-1H-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1H-1,2,3-triazol-1-y l)propanoic acid]-cryptophane-A, PoPo-2-[4-(2-(4-(methoxy)-1H-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1H-1,2,3-triazol-1-yl)propanoic acid]-cryptophane-A, ... | 著者 | Aaron, J.A, Jude, K.M, Di Costanzo, L, Christianson, D.W. | 登録日 | 2008-04-26 | 公開日 | 2008-05-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II. J.Am.Chem.Soc., 130, 2008
|
|
8CX4
| TCR-antigen complex AS8.4-YEIH-HLA*B27 | 分子名称: | AS8.4a, AS8.4b, Beta-2-microglobulin, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-19 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
|
|
8CTG
| Extracellular architecture of an engineered canonical Wnt signaling ternary complex | 分子名称: | Frizzled-8, Low-density lipoprotein receptor-related protein 6, PALMITOLEIC ACID, ... | 著者 | Tsutsumi, N, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-14 | 公開日 | 2023-03-15 | 最終更新日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
6WW2
| Structure of human Frizzled5 by fiducial-assisted cryo-EM | 分子名称: | Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | 著者 | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | 登録日 | 2020-05-07 | 公開日 | 2020-08-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife, 9, 2020
|
|
6WDP
| Interleukin 12 receptor subunit beta-1 | 分子名称: | GLYCEROL, Interleukin-12 receptor subunit beta-1, SULFATE ION | 著者 | Spangler, J.B, Thomas, C, Jude, K.M, Garcia, K.C. | 登録日 | 2020-04-01 | 公開日 | 2021-02-24 | 最終更新日 | 2021-12-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell, 184, 2021
|
|