3F89
 
 | | NEMO CoZi domain | | Descriptor: | NF-kappa-B essential modulator | | Authors: | Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I. | | Deposit date: | 2008-11-11 | | Release date: | 2009-03-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
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4XKH
 | | CRYSTAL STRUCTURE OF THE AIRAPL TANDEM UIMS IN COMPLEX WITH A LYS48-LINKED TRI-UBIQUITIN | | Descriptor: | AN1-type zinc finger protein 2B, Polyubiquitin-C | | Authors: | Rahighi, S, Kawasaki, M, Stanhill, A, Wakatsuki, S. | | Deposit date: | 2015-01-11 | | Release date: | 2016-02-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains.
Structure, 24, 2016
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2ZVN
 | | NEMO CoZi domain incomplex with diubiquitin in P212121 space group | | Descriptor: | NF-kappa-B essential modulator, UBC protein | | Authors: | Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I. | | Deposit date: | 2008-11-12 | | Release date: | 2009-03-24 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
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2ZVO
 | | NEMO CoZi domain in complex with diubiquitin in C2 space group | | Descriptor: | NF-kappa-B essential modulator, UBC protein | | Authors: | Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I. | | Deposit date: | 2008-11-12 | | Release date: | 2009-03-24 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
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7TV4
 | | Crystal structure of NEMO CoZi in complex with HOIP NZF1 and linear diubiquitin | | Descriptor: | E3 ubiquitin-protein ligase RNF31, NF-kappa-B essential modulator, Polyubiquitin-C, ... | | Authors: | Rahighi, S, Iyer, M, Oveisi, H. | | Deposit date: | 2022-02-03 | | Release date: | 2022-08-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain.
Sci Rep, 12, 2022
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6N6R
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6N5M
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6N6S
 | | Crystal structure of ABIN-1 UBAN | | Descriptor: | TNFAIP3-interacting protein 1 | | Authors: | Rahighi, S, Dikic, I, Wakatsuki, S. | | Deposit date: | 2018-11-27 | | Release date: | 2019-07-17 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.
J.Mol.Biol., 431, 2019
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6E08
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6E07
 | | Crystal structure of Canton G6PD in complex with structural NADP | | Descriptor: | GLYCEROL, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Rahighi, S, Mochly-Rosen, D, Wakatsuki, S. | | Deposit date: | 2018-07-06 | | Release date: | 2018-07-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.
Nat Commun, 9, 2018
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4OWF
 | | Crystal structure of the NEMO CoZi in complex with HOIP NZF1 domain | | Descriptor: | E3 ubiquitin-protein ligase RNF31, NF-kappa-B essential modulator, ZINC ION | | Authors: | Rahighi, S, Fujita, H, Kawasaki, M, Kato, R, Iwai, K, Wakatsuki, S. | | Deposit date: | 2014-01-31 | | Release date: | 2014-02-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mechanism Underlying I kappa B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex.
Mol.Cell.Biol., 34, 2014
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4ASW
 | | Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5 | | Descriptor: | SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, UBIQUITIN-LIKE PROTEIN MDY2 | | Authors: | Simon, A.C, Simpson, P.J, Goldstone, R.M, Krysztofinska, E.M, Murray, J.W, High, S, Isaacson, R.L. | | Deposit date: | 2012-05-03 | | Release date: | 2013-01-16 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structure of the Sgt2/Get5 Complex Provides Insights Into Get-Mediated Targeting of Tail-Anchored Membrane Proteins
Proc.Natl.Acad.Sci.USA, 110, 2013
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4ASV
 | | Solution structure of the N-terminal dimerisation domain of Sgt2 | | Descriptor: | SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2 | | Authors: | Simon, A.C, Simpson, P.J, Goldstone, R.M, Krysztofinska, E.M, Murray, J.W, High, S, Isaacson, R.L. | | Deposit date: | 2012-05-03 | | Release date: | 2013-01-16 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Structure of the Sgt2/Get5 Complex Provides Insights Into Get-Mediated Targeting of Tail-Anchored Membrane Proteins
Proc.Natl.Acad.Sci.USA, 110, 2013
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4MRT
 | | Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein | | Descriptor: | 4'-phosphopantetheinyl transferase sfp, COENZYME A, GLYCEROL, ... | | Authors: | Tufar, P, Rahighi, S, Kraas, F.I, Kirchner, D.K, Loehr, F, Henrich, E, Koepke, J, Dikic, I, Guentert, P, Marahiel, M.A, Doetsch, V. | | Deposit date: | 2013-09-17 | | Release date: | 2014-04-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
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2MD9
 | | Solution Structure of an Active Site Mutant Pepitdyl Carrier Protein | | Descriptor: | Tyrocidine synthase 3 | | Authors: | Tufar, P, Rahighi, S, Kraas, F.I, Kirchner, D.K, Loehr, F, Henrich, E, Koepke, J, Dikic, I, Guentert, P, Marahiel, M.A, Doetsch, V. | | Deposit date: | 2013-09-06 | | Release date: | 2014-04-23 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
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6YEK
 | | Crystal structure of human NEMO apo form | | Descriptor: | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b | | Authors: | Garcia-Pardo, J, Akutsu, M, Busse, P, Skenderovic, A, Maculins, T, Dikic, I. | | Deposit date: | 2020-03-25 | | Release date: | 2021-03-03 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell Chem Biol, 27, 2020
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4CPG
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4A20
 | | Crystal structure of the Ubl domain of Mdy2 (Get5) at 1.78A | | Descriptor: | SULFATE ION, UBIQUITIN-LIKE PROTEIN MDY2 | | Authors: | Simon, A.C, Simpson, P.J, Murray, J.W, Isaacson, R.L. | | Deposit date: | 2011-09-21 | | Release date: | 2012-11-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structure of the Sgt2/Get5 Complex Provides Insights Into Get-Mediated Targeting of Tail-Anchored Membrane Proteins
Proc.Natl.Acad.Sci.USA, 110, 2013
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2N9P
 | | Solution structure of RNF126 N-terminal zinc finger domain in complex with BAG6 Ubiquitin-like domain | | Descriptor: | E3 ubiquitin-protein ligase RNF126, Large proline-rich protein BAG6, ZINC ION | | Authors: | Martinez-Lumbreras, S, Krysztofinska, E.M, Thapaliya, A, Isaacson, R.L. | | Deposit date: | 2015-12-01 | | Release date: | 2016-05-25 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural and functional insights into the E3 ligase, RNF126.
Sci Rep, 6, 2016
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2N9O
 | | Solution structure of RNF126 N-terminal zinc finger domain | | Descriptor: | E3 ubiquitin-protein ligase RNF126, ZINC ION | | Authors: | Martinez-Lumbreras, S, Krysztofinska, E.M, Thapaliya, A, Isaacson, R.L. | | Deposit date: | 2015-12-01 | | Release date: | 2016-05-25 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural and functional insights into the E3 ligase, RNF126.
Sci Rep, 6, 2016
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7MCR
 | | Human Apex/Ref1 homodimer formed under oxidative condition | | Descriptor: | DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial, MAGNESIUM ION | | Authors: | Nam, Y.W, Yang, S. | | Deposit date: | 2021-04-02 | | Release date: | 2022-04-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
To Be Published
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7MEV
 | | Human Apex/Ref1 monomer with C138A mutation | | Descriptor: | DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial, GLYCEROL, ... | | Authors: | Nam, Y.W, Yang, S. | | Deposit date: | 2021-04-07 | | Release date: | 2022-04-13 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma
To Be Published
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7T2V
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7T2T
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7T2U
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