2ZVO

NEMO CoZi domain in complex with diubiquitin in C2 space group

Summary for 2ZVO

Related2ZVN 3F89
DescriptorUBC protein, NF-kappa-B essential modulator (3 entities in total)
Functional Keywordsnf-kb signaling, ubiquitin binding, coiled coil, cytoplasm, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger, transcription-signaling protein complex, transcription/signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm  O88522
Total number of polymer chains4
Total molecular weight55911.87
Authors
Rahighi, S.,Ikeda, F.,Kawasaki, M.,Akutsu, M.,Suzuki, N.,Kato, R.,Kensche, T.,Uejima, T.,Bloor, S.,Komander, D.,Randow, F.,Wakatsuki, S.,Dikic, I. (deposition date: 2008-11-12, release date: 2009-03-24, Last modification date: 2017-10-11)
Primary citation
Rahighi, S.,Ikeda, F.,Kawasaki, M.,Akutsu, M.,Suzuki, N.,Kato, R.,Kensche, T.,Uejima, T.,Bloor, S.,Komander, D.,Randow, F.,Wakatsuki, S.,Dikic, I.
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136:1098-1109, 2009
PubMed: 19303852 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2009.03.007
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.273161.5%8.8%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report