1MSB
| |
1RNH
| STRUCTURE OF RIBONUCLEASE H PHASED AT 2 ANGSTROMS RESOLUTION BY MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN | Descriptor: | RIBONUCLEASE HI, SULFATE ION | Authors: | Yang, W, Hendrickson, W.A, Crouch, R.J, Satow, Y. | Deposit date: | 1990-07-11 | Release date: | 1991-10-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein. Science, 249, 1990
|
|
1RZK
| HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | Authors: | Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D. | Deposit date: | 2003-12-24 | Release date: | 2004-02-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120 Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
1RZJ
| HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | Authors: | Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D. | Deposit date: | 2003-12-24 | Release date: | 2004-02-03 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120 Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
1CD8
| |
1CDI
| |
1CDY
| STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 MUTANT WITH GLY 47 REPLACED BY SER | Descriptor: | T-CELL SURFACE GLYCOPROTEIN CD4 | Authors: | Wu, H, Myszka, D, Tendian, S.W, Brouillette, C.G, Sweet, R.W, Chaiken, I.M, Hendrickson, W.A. | Deposit date: | 1996-11-11 | Release date: | 1997-04-01 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proc.Natl.Acad.Sci.USA, 93, 1996
|
|
1CDU
| STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 MUTANT WITH PHE 43 REPLACED BY VAL | Descriptor: | T-CELL SURFACE GLYCOPROTEIN CD4 | Authors: | Wu, H, Myszka, D, Tendian, S.W, Brouillette, C.G, Sweet, R.W, Chaiken, I.M, Hendrickson, W.A. | Deposit date: | 1996-11-11 | Release date: | 1997-04-01 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proc.Natl.Acad.Sci.USA, 93, 1996
|
|
1CNT
| CILIARY NEUROTROPHIC FACTOR | Descriptor: | CILIARY NEUROTROPHIC FACTOR, SULFATE ION, YTTERBIUM (III) ION | Authors: | Mcdonald, N.Q, Panayotatos, N, Hendrickson, W.A. | Deposit date: | 1996-06-06 | Release date: | 1997-03-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J., 14, 1995
|
|
1DJS
| |
1DKX
| THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 SELENOMETHIONYL CRYSTALS | Descriptor: | SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES) | Authors: | Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A. | Deposit date: | 1996-06-03 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272, 1996
|
|
1DKZ
| THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 NATIVE CRYSTALS | Descriptor: | SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES) | Authors: | Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A. | Deposit date: | 1996-06-03 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272, 1996
|
|
1DKY
| THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 2 NATIVE CRYSTALS | Descriptor: | DNAK, PEPTIDE SUBSTRATE | Authors: | Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A. | Deposit date: | 1996-06-03 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272, 1996
|
|
1FIT
| FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) | Descriptor: | FRAGILE HISTIDINE PROTEIN, SULFATE ION, beta-D-fructofuranose | Authors: | Lima, C.D, D'Amico, K.L, Naday, I, Rosenbaum, G, Westbrook, E.M, Hendrickson, W.A. | Deposit date: | 1997-05-17 | Release date: | 1997-11-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family. Structure, 5, 1997
|
|
1GC1
| HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, CD4, ... | Authors: | Kwong, P.D, Wyatt, R, Robinson, J, Sweet, R.W, Sodroski, J, Hendrickson, W.A. | Deposit date: | 1998-06-15 | Release date: | 1998-07-08 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature, 393, 1998
|
|
1IRK
| CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR | Descriptor: | ETHYL MERCURY ION, INSULIN RECEPTOR TYROSINE KINASE DOMAIN | Authors: | Hubbard, S.R, Wei, L, Ellis, L, Hendrickson, W.A. | Deposit date: | 1995-01-02 | Release date: | 1995-02-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature, 372, 1994
|
|
1KPF
| PKCI-SUBSTRATE ANALOG | Descriptor: | ADENOSINE MONOPHOSPHATE, PROTEIN KINASE C INTERACTING PROTEIN | Authors: | Lima, C.D, Klein, M.G, Hendrickson, W.A. | Deposit date: | 1997-09-25 | Release date: | 1998-03-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-based analysis of catalysis and substrate definition in the HIT protein family. Science, 278, 1997
|
|
1KPE
| PKCI-TRANSITION STATE ANALOG | Descriptor: | ADENOSINE-5'-DITUNGSTATE, PROTEIN KINASE C INTERACTING PROTEIN | Authors: | Lima, C.D, Klein, M.G, Hendrickson, W.A. | Deposit date: | 1997-09-25 | Release date: | 1998-03-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based analysis of catalysis and substrate definition in the HIT protein family. Science, 278, 1997
|
|
7TJP
| HIV-1 gp120 complex with CJF-II-195 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, IMIDAZOLE, ... | Authors: | Gong, Z, Hendrickson, W.A. | Deposit date: | 2022-01-16 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines Acs Medicinal Chemistry Letters, 14, 2023
|
|
7TJO
| HIV-1 gp120 complex with CJF-II-197-S | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, IMIDAZOLE, ... | Authors: | Gong, Z, Hendrickson, W.A. | Deposit date: | 2022-01-16 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines ACS Medicinal Chemistry Letters, 14, 2023
|
|
7SIN
| Structure of negative allosteric modulator-bound inactive human calcium-sensing receptor | Descriptor: | 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile, Isoform 1 of Extracellular calcium-sensing receptor | Authors: | Park, J, Zuo, H, Frangaj, A, Fu, Z, Yen, L.Y, Zhang, Z, Mosyak, L, Slavkovich, V.N, Liu, J, Ray, K.M, Cao, B, Vallese, F, Geng, Y, Chen, S, Grassucci, R, Dandey, V.P, Tan, Y.Z, Eng, E, Lee, Y, Kloss, B, Liu, Z, Hendrickson, W.A, Potter, C.S, Carragher, B, Graziano, J, Conigrave, A.D, Frank, J, Clarke, O.B, Fan, Q.R. | Deposit date: | 2021-10-14 | Release date: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Symmetric activation and modulation of the human calcium-sensing receptor. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7SIL
| Structure of positive allosteric modulator-bound active human calcium-sensing receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ... | Authors: | Park, J, Zuo, H, Frangaj, A, Fu, Z, Yen, L.Y, Zhang, Z, Mosyak, L, Slavkovich, V.N, Liu, J, Ray, K.M, Cao, B, Vallese, F, Geng, Y, Chen, S, Grassucci, R, Dandey, V.P, Tan, Y.Z, Eng, E, Lee, Y, Kloss, B, Liu, Z, Hendrickson, W.A, Potter, C.S, Carragher, B, Graziano, J, Conigrave, A.D, Frank, J, Clarke, O.B, Fan, Q.R. | Deposit date: | 2021-10-14 | Release date: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Symmetric activation and modulation of the human calcium-sensing receptor. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
1NEU
| STRUCTURE OF MYELIN MEMBRANE ADHESION MOLECULE P0 | Descriptor: | MYELIN P0 PROTEIN | Authors: | Shapiro, L, Doyle, J.P, Hensley, P, Colman, D.R, Hendrickson, W.A. | Deposit date: | 1996-09-24 | Release date: | 1997-05-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin. Neuron, 17, 1996
|
|
1NCJ
| N-CADHERIN, TWO-DOMAIN FRAGMENT | Descriptor: | CALCIUM ION, PROTEIN (N-CADHERIN), URANYL (VI) ION | Authors: | Tamura, K, Shan, W.-S, Hendrickson, W.A, Colman, D.R, Shapiro, L. | Deposit date: | 1999-02-02 | Release date: | 1999-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron, 20, 1998
|
|
1NCH
| STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS | Descriptor: | N-CADHERIN, YTTERBIUM (III) ION | Authors: | Shapiro, L, Fannon, A.M, Kwong, P.D, Thompson, A, Lehmann, M.S, Grubel, G, Legrand, J.-F, Als-Nielsen, J, Colman, D.R, Hendrickson, W.A. | Deposit date: | 1995-03-23 | Release date: | 1995-07-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of cell-cell adhesion by cadherins. Nature, 374, 1995
|
|