7SIN

Structure of negative allosteric modulator-bound inactive human calcium-sensing receptor

Summary for 7SIN

Entry DOI	10.2210/pdb7sin/pdb
EMDB information	25145
Descriptor	Isoform 1 of Extracellular calcium-sensing receptor, 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile (2 entities in total)
Functional Keywords	calcium-sensing receptor, cryo-em structure, allosteric modulation, activation mechanism, symmetry, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	199416.76
Authors	Park, J.,Zuo, H.,Frangaj, A.,Fu, Z.,Yen, L.Y.,Zhang, Z.,Mosyak, L.,Slavkovich, V.N.,Liu, J.,Ray, K.M.,Cao, B.,Vallese, F.,Geng, Y.,Chen, S.,Grassucci, R.,Dandey, V.P.,Tan, Y.Z.,Eng, E.,Lee, Y.,Kloss, B.,Liu, Z.,Hendrickson, W.A.,Potter, C.S.,Carragher, B.,Graziano, J.,Conigrave, A.D.,Frank, J.,Clarke, O.B.,Fan, Q.R. (deposition date: 2021-10-14, release date: 2022-01-19)
Primary citation	Park, J.,Zuo, H.,Frangaj, A.,Fu, Z.,Yen, L.Y.,Zhang, Z.,Mosyak, L.,Slavkovich, V.N.,Liu, J.,Ray, K.M.,Cao, B.,Vallese, F.,Geng, Y.,Chen, S.,Grassucci, R.,Dandey, V.P.,Tan, Y.Z.,Eng, E.,Lee, Y.,Kloss, B.,Liu, Z.,Hendrickson, W.A.,Potter, C.S.,Carragher, B.,Graziano, J.,Conigrave, A.D.,Frank, J.,Clarke, O.B.,Fan, Q.R. Symmetric activation and modulation of the human calcium-sensing receptor. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34916296 DOI: 10.1073/pnas.2115849118 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.9 Å)

Structure validation