7SIN
Structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Isoform 1 of Extracellular calcium-sensing receptor | polymer | 878 | 99299.5 | 2 | UniProt (P41180-1) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) UniProt (by SIFTS) (P41180) In PDB | Homo sapiens (Human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
| 2 | A, B | 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile | non-polymer | 408.9 | 2 | Chemie (YP1) |
Sequence modifications
A, B: 1 - 870 (UniProt: P41180-1)
| PDB | External Database | Details |
|---|---|---|
| Asp 871 | - | expression tag |
| Tyr 872 | - | expression tag |
| Lys 873 | - | expression tag |
| Asp 874 | - | expression tag |
| Asp 875 | - | expression tag |
| Asp 876 | - | expression tag |
| Asp 877 | - | expression tag |
| Lys 878 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 198598.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 817.8 | |
| All* | Total formula weight | 199416.8 |
