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1NCH

STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS

Summary for 1NCH
Entry DOI10.2210/pdb1nch/pdb
DescriptorN-CADHERIN, YTTERBIUM (III) ION (3 entities in total)
Functional Keywordscadherin, cell adhesion protein
Biological sourceMus musculus (house mouse)
Total number of polymer chains2
Total formula weight24835.71
Authors
Shapiro, L.,Fannon, A.M.,Kwong, P.D.,Thompson, A.,Lehmann, M.S.,Grubel, G.,Legrand, J.-F.,Als-Nielsen, J.,Colman, D.R.,Hendrickson, W.A. (deposition date: 1995-03-23, release date: 1995-07-10, Last modification date: 2024-02-14)
Primary citationShapiro, L.,Fannon, A.M.,Kwong, P.D.,Thompson, A.,Lehmann, M.S.,Grubel, G.,Legrand, J.F.,Als-Nielsen, J.,Colman, D.R.,Hendrickson, W.A.
Structural basis of cell-cell adhesion by cadherins.
Nature, 374:327-337, 1995
Cited by
PubMed Abstract: Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.
PubMed: 7885471
DOI: 10.1038/374327a0
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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