7B2Q
 
 | | Cryo-EM structure of complement C4b in complex with nanobody B12 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody B12, ... | | Authors: | Oosterheert, W, De la O Becerra, K.I, Gros, P. | | Deposit date: | 2020-11-27 | | Release date: | 2022-03-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Multifaceted Activities of Seven Nanobodies against Complement C4b.
J Immunol., 208, 2022
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7B2P
 | | Cryo-EM structure of complement C4b in complex with nanobody B5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4 alpha chain, ... | | Authors: | Oosterheert, W, De la O Becerra, K.I, Gros, P. | | Deposit date: | 2020-11-27 | | Release date: | 2022-03-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Multifaceted Activities of Seven Nanobodies against Complement C4b.
J Immunol., 208, 2022
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7B2M
 | | Cryo-EM structure of complement C4b in complex with nanobody E3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody E3, Complement C4 alpha chain, ... | | Authors: | Oosterheert, W, De la O Becerra, K.I, van den Bos, R.M, Gros, P. | | Deposit date: | 2020-11-27 | | Release date: | 2022-03-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Multifaceted Activities of Seven Nanobodies against Complement C4b.
J Immunol., 208, 2022
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1FE8
 | | CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, IMMUNOGLOBULIN IGG RU5, ... | | Authors: | Bouma, B, Huizinga, E.G, Schiphorst, M.E, Sixma, J.J, Kroon, J, Gros, P. | | Deposit date: | 2000-07-21 | | Release date: | 2001-04-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Identification of the collagen-binding site of the von Willebrand factor A3-domain.
J.Biol.Chem., 276, 2001
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6Y9B
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5O35
 | | Structure of complement proteins complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H | | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | | Deposit date: | 2017-05-23 | | Release date: | 2017-06-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
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5O32
 | | The structure of complement complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | | Deposit date: | 2017-05-23 | | Release date: | 2017-06-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (4.206209 Å) | | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
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7BAG
 | | C3b in complex with CP40 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETAMIDE, AMINO GROUP, ... | | Authors: | Lamers, C, Xue, X, Smiesko, M, van Son, H, Wagner, B, Sfyroera, G, Gros, P, Lambris, J, Ricklin, D. | | Deposit date: | 2020-12-15 | | Release date: | 2022-01-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors.
Nat Commun, 13, 2022
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1UYN
 | | Translocator domain of autotransporter NalP from Neisseria meningitidis | | Descriptor: | NALP, PENTAETHYLENE GLYCOL MONODECYL ETHER, SULFATE ION | | Authors: | Oomen, C.J, Van Ulsen, P, Van Gelder, P, Feijen, M, Tommassen, J, Gros, P. | | Deposit date: | 2004-03-02 | | Release date: | 2004-03-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the Translocator Domain of a Bacterial Autotransporter
Embo J., 23, 2004
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1UYO
 | | Translocator domain of autotransporter NalP from Neisseria meningitidis | | Descriptor: | NALP, PENTAETHYLENE GLYCOL MONODECYL ETHER | | Authors: | Oomen, C.J, Van Ulsen, P, Van Gelder, P, Feijen, M, Tommassen, J, Gros, P. | | Deposit date: | 2004-03-02 | | Release date: | 2004-03-19 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure of the Translocator Domain of a Bacterial Autotransporter
Embo J., 23, 2004
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5NSC
 | | Fc DEKK heterodimer variant | | Descriptor: | Fc-III peptide, GLYCEROL, Putative uncharacterized protein DKFZp686C11235, ... | | Authors: | De Nardis, C, Hendriks, L.J.A, Poirier, E, Arvinte, T, Gros, P, Bakker, A.B.H, de Kruif, J. | | Deposit date: | 2017-04-26 | | Release date: | 2017-07-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
J. Biol. Chem., 292, 2017
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5O7P
 | | HER3 in complex with Fab MF3178 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MF3178 FAB heavy chain, MF3178 FAB light chain, ... | | Authors: | De Nardis, C, Gros, P. | | Deposit date: | 2017-06-09 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (4.5 Å) | | Cite: | Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
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5NSG
 | | Fc DEDE homodimer variant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Putative uncharacterized protein DKFZp686C11235, ... | | Authors: | De Nardis, C, Hendriks, L.J.A, Poirier, E, Arvinte, T, Gros, P, Bakker, A.B.H, de Kruif, J. | | Deposit date: | 2017-04-26 | | Release date: | 2017-07-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
J. Biol. Chem., 292, 2017
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5O4G
 | | HER2 in complex with Fab MF3958 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MF3958 FAB heavy chain, ... | | Authors: | De Nardis, C, Gros, P. | | Deposit date: | 2017-05-29 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
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5O4O
 | | HER3 in complex with Fab MF3178 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MF3178 FAB heavy chain, ... | | Authors: | De Nardis, C, Gros, P. | | Deposit date: | 2017-05-30 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
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6S08
 | | Crystal Structure of Properdin (TSR domains N1 & 456) | | Descriptor: | Properdin, SODIUM ION, TRIETHYLENE GLYCOL, ... | | Authors: | van den Bos, R.M, Pearce, N.M, Gros, P. | | Deposit date: | 2019-06-14 | | Release date: | 2019-09-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
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6RLR
 | | Crystal structure of CD9 large extracellular loop | | Descriptor: | CD9 antigen | | Authors: | Neviani, V, Kroon-Batenburg, L, Lutz, M, Pearce, N.M, Pos, W, Schotte, R, Spits, H, Gros, P. | | Deposit date: | 2019-05-02 | | Release date: | 2020-09-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F.
Life Sci Alliance, 3, 2020
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6S0A
 | | Crystal Structure of Properdin (TSR domains N12 & 456) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Properdin, alpha-D-mannopyranose, ... | | Authors: | van den Bos, R.M, Pearce, N.M, Gros, P. | | Deposit date: | 2019-06-14 | | Release date: | 2019-09-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
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6S0B
 | | Crystal Structure of Properdin in complex with the CTC domain of C3/C3b | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Properdin, ... | | Authors: | van den Bos, R.M, Pearce, N.M, Gros, P. | | Deposit date: | 2019-06-14 | | Release date: | 2019-09-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.312 Å) | | Cite: | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
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6RLM
 | | Crystal structure of AT1412dm Fab fragment | | Descriptor: | AT1412dm Fab (Heavy Chain), AT1412dm Fab (Light Chain), CHLORIDE ION | | Authors: | Neviani, V, Pearce, N.M, Pos, W, Schotte, R, Spits, H, Gros, P. | | Deposit date: | 2019-05-02 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of a homo-dimerization site in tetraspanin CD9 targeted by a melanoma patient-derived antibody
To Be Published
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6RLO
 | | Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop | | Descriptor: | AT1412dm Fab Fragment (Heavy Chain), AT1412dm Fab Fragment (Light Chain), CD9 antigen, ... | | Authors: | Neviani, V, Pearce, N.M, Pos, W, Schotte, R, Spits, H, Gros, P. | | Deposit date: | 2019-05-02 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of a homo-dimerization site in tetraspanin CD9 targeted by a melanoma patient-derived antibody
To Be Published
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1MPA
 | | BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS | | Descriptor: | CADMIUM ION, MN12H2 IGG2A-KAPPA, PORA P1.16 PEPTIDE FLUORESCEIN CONJUGATE | | Authors: | Van Den Elsen, J.M.H, Herron, J.N, Kroon, J, Gros, P. | | Deposit date: | 1997-02-26 | | Release date: | 1997-09-04 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.
Proteins, 29, 1997
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6FCZ
 | | Model of gC1q-Fc complex based on 7A EM map | | Descriptor: | Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ... | | Authors: | Ugurlar, D, Howes, S.C, de Kreuk, B.J.K, de Jong, R.N, Beurskens, F.J, Koster, A.J, Parren, P.W.H.I, Sharp, T.H, Gros, P, Koning, R.I. | | Deposit date: | 2017-12-21 | | Release date: | 2018-02-28 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
Science, 359, 2018
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1I78
 | | CRYSTAL STRUCTURE OF OUTER MEMBRANE PROTEASE OMPT FROM ESCHERICHIA COLI | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PROTEASE VII, octyl beta-D-glucopyranoside | | Authors: | Vandeputte-Rutten, L, Kramer, R.A, Kroon, J, Dekker, N, Egmond, M.R, Gros, P. | | Deposit date: | 2001-03-08 | | Release date: | 2001-10-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site.
EMBO J., 20, 2001
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1I8N
 | | CRYSTAL STRUCTURE OF LEECH ANTI-PLATELET PROTEIN | | Descriptor: | ANTI-PLATELET PROTEIN, PROPIONAMIDE | | Authors: | Huizinga, E.G, Schouten, A, Connolly, T.M, Kroon, J, Sixma, J.J, Gros, P. | | Deposit date: | 2001-03-15 | | Release date: | 2001-08-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The structure of leech anti-platelet protein, an inhibitor of haemostasis.
Acta Crystallogr.,Sect.D, 57, 2001
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