5NSC

Fc DEKK heterodimer variant

Summary for 5NSC

• Entry DOI: 10.2210/pdb5nsc/pdb
• Descriptor: Putative uncharacterized protein DKFZp686C11235, Fc-III peptide, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: igg, fc heterodimer, l351d/l368e + l351k/t366k, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 56798.45

Authors

De Nardis, C.,Hendriks, L.J.A.,Poirier, E.,Arvinte, T.,Gros, P.,Bakker, A.B.H.,de Kruif, J. (deposition date: 2017-04-26, release date: 2017-07-05, Last modification date: 2024-01-17)

• Primary citation: De Nardis, C.,Hendriks, L.J.A.,Poirier, E.,Arvinte, T.,Gros, P.,Bakker, A.B.H.,de Kruif, J.; A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.; J. Biol. Chem., 292:14706-14717, 2017; PubMed: 28655766; DOI: 10.1074/jbc.M117.793497

Experimental method

X-RAY DIFFRACTION (2.3 Å)