5NSC
Fc DEKK heterodimer variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Putative uncharacterized protein DKFZp686C11235 | polymer | 232 | 26186.7 | 1 | UniProt (Q6MZV7) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B (B) | Putative uncharacterized protein DKFZp686C11235 | polymer | 232 | 26049.2 | 1 | UniProt (Q6MZV7) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | Fc-III peptide | polymer | 13 | 1533.7 | 1 | synthetic construct | ||
| 4 | D, E (D, E) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1422.3 | 2 | In PDB GlyTouCan (G61334IA) | |||
| 5 | F, G (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | H, I, J (A, B, C) | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A: 216 - 447 (UniProt: Q6MZV7)
B: 216 - 447 (UniProt: Q6MZV7)
| PDB | External Database | Details |
|---|---|---|
| Ser 220 | Cys 246 | conflict |
| Lys 351 | Leu 377 | engineered mutation |
| Lys 366 | Thr 392 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 220 | Cys 246 | conflict |
| Glu 252 | Met 278 | engineered mutation |
| Ala 253 | Ile 279 | engineered mutation |
| Asp 351 | Leu 377 | engineered mutation |
| Glu 368 | Leu 394 | engineered mutation |
| Ala 435 | His 461 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53769.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2844.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 184.2 | |
| All* | Total formula weight | 56798.5 |
