5NSC

Fc DEKK heterodimer variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Putative uncharacterized protein DKFZp686C11235	polymer	232	26186.7	1	UniProt (Q6MZV7)	Homo sapiens (Human)
2	B (B)	Putative uncharacterized protein DKFZp686C11235	polymer	232	26049.2	1	UniProt (Q6MZV7)	Homo sapiens (Human)
3	C (C)	Fc-III peptide	polymer	13	1533.7	1		synthetic construct
4	D, E (D, E)	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1422.3	2	In PDB GlyTouCan (G61334IA)
5	F, G (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	H, I, J (A, B, C)	water	water		18.0	186	Chemie (HOH)

Sequence modifications

A: 216 - 447 (UniProt: Q6MZV7)

PDB	External Database	Details
Ser 220	Cys 246	conflict
Lys 351	Leu 377	engineered mutation
Lys 366	Thr 392	engineered mutation

B: 216 - 447 (UniProt: Q6MZV7)

PDB	External Database	Details
Ser 220	Cys 246	conflict
Glu 252	Met 278	engineered mutation
Ala 253	Ile 279	engineered mutation
Asp 351	Leu 377	engineered mutation
Glu 368	Leu 394	engineered mutation
Ala 435	His 461	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	53769.7
Branched	Number of molecules	2
	Total formula weight	2844.6
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	56798.5

*Water molecules are not included.