5O4G

HER2 in complex with Fab MF3958

Summary for 5O4G

• Entry DOI: 10.2210/pdb5o4g/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-2, MF3958 FAB light chain, MF3958 FAB heavy chain, ... (6 entities in total)
• Functional Keywords: her2 ectodomain, complex, fab, transferase, oncoprotein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 118196.12

Authors

De Nardis, C.,Gros, P. (deposition date: 2017-05-29, release date: 2018-05-16, Last modification date: 2024-01-17)

• Primary citation: Geuijen, C.A.W.,De Nardis, C.,Maussang, D.,Rovers, E.,Gallenne, T.,Hendriks, L.J.A.,Visser, T.,Nijhuis, R.,Logtenberg, T.,de Kruif, J.,Gros, P.,Throsby, M.; Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.; Cancer Cell, 33:922-936.e10, 2018; PubMed: 29763625; DOI: 10.1016/j.ccell.2018.04.003

Experimental method

X-RAY DIFFRACTION (3 Å)