3E2H
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3E3Q
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3EEB
| Structure of the V. cholerae RTX cysteine protease domain | Descriptor: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION | Authors: | Lupardus, P.J, Shen, A, Bogyo, M, Garcia, K.C. | Deposit date: | 2008-09-04 | Release date: | 2008-10-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain Science, 322, 2008
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4F0A
| Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-8, PALMITOLEIC ACID, ... | Authors: | Janda, C.Y, Waghray, D, Levin, A.M, Thomas, C, Garcia, K.C. | Deposit date: | 2012-05-03 | Release date: | 2012-06-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural basis of Wnt recognition by Frizzled. Science, 337, 2012
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3GCD
| Structure of the V. cholerae RTX cysteine protease domain in complex with an aza-Leucine peptide inhibitor | Descriptor: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION, ... | Authors: | Lupardus, P.J, Garcia, K.C, Shen, A, Bogyo, M. | Deposit date: | 2009-02-21 | Release date: | 2009-05-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nat.Chem.Biol., 5, 2009
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4GAF
| Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EBI-005, Interleukin-1 receptor type 1, ... | Authors: | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | Deposit date: | 2012-07-25 | Release date: | 2013-02-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
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4GAI
| Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra | Descriptor: | EBI-005 | Authors: | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | Deposit date: | 2012-07-25 | Release date: | 2013-02-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
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2PXY
| Crystal structures of immune receptor complexes | Descriptor: | H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain, ... | Authors: | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | Deposit date: | 2007-05-14 | Release date: | 2007-10-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat.Immunol., 8, 2007
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2RKC
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8DH8
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8DHA
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8DH9
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8DA7
| Coevolved affibody-Z domain pair LL1.c6 | Descriptor: | Immunoglobulin G-binding protein A, MALONATE ION, affibody LL1.FIFV | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA8
| Coevolved affibody-Z domain pair LL2.c1 | Descriptor: | Affibody LL2.FIIK, GLYCEROL, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA9
| Coevolved affibody-Z domain pair LL2.c3 | Descriptor: | Affibody LL2.FIIV, GLYCEROL, Immunoglobulin G-binding protein A, ... | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DAC
| Coevolved affibody-Z domain pair LL2.c22 | Descriptor: | Affibody LL2.FILV, GLYCEROL, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA3
| Coevolved affibody-Z domain pair LL1.c1 | Descriptor: | Affibody LL1.FILF, Immunoglobulin G-binding protein A, MALONATE ION, ... | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA4
| Coevolved affibody-Z domain pair LL1.c2 | Descriptor: | Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ... | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DAB
| Coevolved affibody-Z domain pair LL2.c17 | Descriptor: | Affibody LL2.IVVY, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.134 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA6
| Coevolved affibody-Z domain pair LL1.c5 | Descriptor: | Affibody LL1.FIIM, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DA5
| Coevolved affibody-Z domain pair LL1.c4 | Descriptor: | GLYCEROL, Immunoglobulin G-binding protein A, affibody LL1.FIVM | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DAA
| Coevolved affibody-Z domain pair LL2.c7 | Descriptor: | Affibody LL2.FIVK, Immunoglobulin G-binding protein A, MALONATE ION | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DZ8
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8ENT
| Interleukin-21 signaling complex with IL-21R and IL-2Rg | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-09-30 | Release date: | 2023-06-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | A structural blueprint for interleukin-21 signal modulation. Cell Rep, 42, 2023
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8FFE
| Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | Descriptor: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | Authors: | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | Deposit date: | 2022-12-08 | Release date: | 2023-03-08 | Last modified: | 2023-03-22 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
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