3E2H
 
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3E3Q
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3EEB
 | | Structure of the V. cholerae RTX cysteine protease domain | | 分子名称: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION | | 著者 | Lupardus, P.J, Shen, A, Bogyo, M, Garcia, K.C. | | 登録日 | 2008-09-04 | | 公開日 | 2008-10-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain
Science, 322, 2008
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4F0A
 | | Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-8, PALMITOLEIC ACID, ... | | 著者 | Janda, C.Y, Waghray, D, Levin, A.M, Thomas, C, Garcia, K.C. | | 登録日 | 2012-05-03 | | 公開日 | 2012-06-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Structural basis of Wnt recognition by Frizzled.
Science, 337, 2012
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3GCD
 | | Structure of the V. cholerae RTX cysteine protease domain in complex with an aza-Leucine peptide inhibitor | | 分子名称: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION, ... | | 著者 | Lupardus, P.J, Garcia, K.C, Shen, A, Bogyo, M. | | 登録日 | 2009-02-21 | | 公開日 | 2009-05-26 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Nat.Chem.Biol., 5, 2009
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4GAF
 | | Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EBI-005, Interleukin-1 receptor type 1, ... | | 著者 | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | | 登録日 | 2012-07-25 | | 公開日 | 2013-02-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Design of a superior cytokine antagonist for topical ophthalmic use.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4GAI
 | | Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra | | 分子名称: | EBI-005 | | 著者 | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | | 登録日 | 2012-07-25 | | 公開日 | 2013-02-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Design of a superior cytokine antagonist for topical ophthalmic use.
Proc.Natl.Acad.Sci.USA, 110, 2013
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2PXY
 | | Crystal structures of immune receptor complexes | | 分子名称: | H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain, ... | | 著者 | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | | 登録日 | 2007-05-14 | | 公開日 | 2007-10-09 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
Nat.Immunol., 8, 2007
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2RKC
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8DH8
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8DHA
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8DH9
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8DA7
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8DA8
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8DA9
 | | Coevolved affibody-Z domain pair LL2.c3 | | 分子名称: | Affibody LL2.FIIV, GLYCEROL, Immunoglobulin G-binding protein A, ... | | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | | 登録日 | 2022-06-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DAC
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8DA3
 | | Coevolved affibody-Z domain pair LL1.c1 | | 分子名称: | Affibody LL1.FILF, Immunoglobulin G-binding protein A, MALONATE ION, ... | | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | | 登録日 | 2022-06-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DA4
 | | Coevolved affibody-Z domain pair LL1.c2 | | 分子名称: | Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ... | | 著者 | Jude, K.M, Yang, A, Garcia, K.C. | | 登録日 | 2022-06-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DAB
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8DA6
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8DA5
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8DAA
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8DZ8
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8ENT
 | | Interleukin-21 signaling complex with IL-21R and IL-2Rg | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | | 登録日 | 2022-09-30 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | A structural blueprint for interleukin-21 signal modulation.
Cell Rep, 42, 2023
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8FFE
 | | Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | | 分子名称: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | | 著者 | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | | 登録日 | 2022-12-08 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-03-22 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc.Natl.Acad.Sci.USA, 120, 2023
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