6VKL
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![BU of 6vkl by Molmil](/molmil-images/mine/6vkl) | Negative stain reconstruction of the yeast exocyst octameric complex. | Descriptor: | Exocyst complex component EXO70, Exocyst complex component EXO84, Exocyst complex component SEC10, ... | Authors: | Frost, A, Munson, M. | Deposit date: | 2020-01-21 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (15 Å) | Cite: | Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases. J. Cell Biol., 219, 2020
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5WP9
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![BU of 5wp9 by Molmil](/molmil-images/mine/5wp9) | Structural Basis of Mitochondrial Receptor Binding and Constriction by Dynamin-Related Protein 1 | Descriptor: | Dynamin-1-like protein, MAGNESIUM ION, Mitochondrial dynamics protein MID49, ... | Authors: | Kalia, R, Wang, R.Y.R, Yusuf, A, Thomas, P.V, Agard, D.A, Shaw, J.M, Frost, A. | Deposit date: | 2017-08-03 | Release date: | 2018-06-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.22 Å) | Cite: | Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature, 558, 2018
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7LVK
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![BU of 7lvk by Molmil](/molmil-images/mine/7lvk) | Cfr-modified 50S subunit from Escherichia coli | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Stojkovic, V, Myasnikov, A.G, Frost, A, Fujimori, D.G. | Deposit date: | 2021-02-25 | Release date: | 2021-12-15 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Investigating antibiotic resistance of a ribosomal-RNA methylating enzyme through directed evolution To Be Published
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6CAJ
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![BU of 6caj by Molmil](/molmil-images/mine/6caj) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Tsai, J.C, Miller-Vedam, L.E, Anand, A.A, Jaishankar, P, Nguyen, H.C, Renslo, A.R, Frost, A, Walter, P. | Deposit date: | 2018-01-31 | Release date: | 2018-04-11 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science, 359, 2018
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6E8G
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7ADO
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![BU of 7ado by Molmil](/molmil-images/mine/7ado) | Cryo-EM structure of human ER membrane protein complex in lipid nanodiscs | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ... | Authors: | Braeuning, B, Prabu, J.R, Miller-Vedam, L.E, Weissman, J.S, Frost, A, Schulman, B.A. | Deposit date: | 2020-09-15 | Release date: | 2020-12-02 | Last modified: | 2021-01-20 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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7ADP
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![BU of 7adp by Molmil](/molmil-images/mine/7adp) | Cryo-EM structure of human ER membrane protein complex in GDN detergent | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ... | Authors: | Braeuning, B, Prabu, J.R, Miller-Vedam, L.E, Weissman, J.S, Frost, A, Schulman, B.A. | Deposit date: | 2020-09-15 | Release date: | 2020-12-02 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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6PJ6
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![BU of 6pj6 by Molmil](/molmil-images/mine/6pj6) | High resolution cryo-EM structure of E.coli 50S | Descriptor: | 23S rRNA, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | Authors: | Stojkovic, V, Myasnikov, A, Frost, A, Fujimori, D.G. | Deposit date: | 2019-06-27 | Release date: | 2020-01-22 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit. Nucleic Acids Res., 48, 2020
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3JC1
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![BU of 3jc1 by Molmil](/molmil-images/mine/3jc1) | Electron cryo-microscopy of the IST1-CHMP1B ESCRT-III copolymer | Descriptor: | Charged multivesicular body protein 1b, Increased Sodium Tolerance 1 (IST1) | Authors: | McCullough, J, Clippinger, A.K, Talledge, N, Skowyra, M.L, Saunders, M.G, Naismith, T.V, Colf, L.A, Afonine, P, Arthur, C, Sundquist, W.I, Hanson, P.I, Frost, A. | Deposit date: | 2015-11-09 | Release date: | 2015-12-16 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure and membrane remodeling activity of ESCRT-III helical polymers. Science, 350, 2015
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7L7G
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![BU of 7l7g by Molmil](/molmil-images/mine/7l7g) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (updated model of PDB ID: 6CAJ) | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Tsai, J.C, Miller-Vedam, L.E, Anand, A, Jaishankar, P, Nguyen, H.C, Wang, L, Renslo, A.R, Frost, A, Walter, P. | Deposit date: | 2020-12-28 | Release date: | 2021-03-24 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | eIF2B conformation and assembly state regulates the integrated stress response. Elife, 10, 2021
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7SSP
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7SSS
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![BU of 7sss by Molmil](/molmil-images/mine/7sss) | Structure of the NADH-bound human COQ7:COQ9 complex by single-particle electron cryo-microscopy | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-[(2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL]PHENOL, 5-demethoxyubiquinone hydroxylase, ... | Authors: | Aydin, H, Frost, A. | Deposit date: | 2021-11-11 | Release date: | 2022-11-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structure and functionality of a multimeric human COQ7:COQ9 complex. Mol.Cell, 82, 2022
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6O81
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![BU of 6o81 by Molmil](/molmil-images/mine/6o81) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation initiation factor 2 from Homo sapiens | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, ... | Authors: | Nguyen, H, Kenner, L, Frost, A. | Deposit date: | 2019-03-08 | Release date: | 2019-05-15 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science, 364, 2019
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7TRJ
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![BU of 7trj by Molmil](/molmil-images/mine/7trj) | The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta subunit | Descriptor: | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... | Authors: | Wang, L, Schoof, M, Lawrence, R, Boone, M, Frost, A, Walter, P. | Deposit date: | 2022-01-29 | Release date: | 2022-04-27 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. Elife, 11, 2022
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6TZ9
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6TZ4
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6TZA
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6TZ5
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7JK9
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![BU of 7jk9 by Molmil](/molmil-images/mine/7jk9) | Helical filaments of plant light-dependent protochlorophyllide oxidoreductase (LPOR) bound to NADPH, Pchlide, and membrane | Descriptor: | 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Protochlorophyllide, ... | Authors: | Nguyen, H.C, Gabruk, M, Frost, A. | Deposit date: | 2020-07-28 | Release date: | 2021-03-17 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis. Nat.Plants, 7, 2021
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7KTX
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![BU of 7ktx by Molmil](/molmil-images/mine/7ktx) | Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to a Fab in DDM detergent | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ... | Authors: | Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A. | Deposit date: | 2020-11-24 | Release date: | 2020-12-02 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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7KRA
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![BU of 7kra by Molmil](/molmil-images/mine/7kra) | Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ... | Authors: | Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A. | Deposit date: | 2020-11-19 | Release date: | 2020-12-02 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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7KOD
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![BU of 7kod by Molmil](/molmil-images/mine/7kod) | Cryo-EM structure of heavy chain mouse apoferritin | Descriptor: | Ferritin heavy chain | Authors: | Sun, M, Azumaya, C, Tse, E, Frost, A, Southworth, D, Verba, K.A, Cheng, Y, Agard, D.A. | Deposit date: | 2020-11-08 | Release date: | 2020-12-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (1.655 Å) | Cite: | Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. J.Struct.Biol., 213, 2021
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7L70
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![BU of 7l70 by Molmil](/molmil-images/mine/7l70) | The eukaryotic translation initiation factor 2B from Homo sapiens in its apo form | Descriptor: | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... | Authors: | Wang, L, Schoof, M, Lawrence, R, Boone, M, Frost, A, Walter, P. | Deposit date: | 2020-12-24 | Release date: | 2021-03-24 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | eIF2B conformation and assembly state regulates the integrated stress response. Elife, 10, 2021
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6CNL
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![BU of 6cnl by Molmil](/molmil-images/mine/6cnl) | Crystal Structure of H105A PGAM5 Dodecamer | Descriptor: | MAGNESIUM ION, PGAM5 Multimerization Motif Peptide, Serine/threonine-protein phosphatase PGAM5, ... | Authors: | Ruiz, K, Agnew, C, Jura, N. | Deposit date: | 2018-03-08 | Release date: | 2019-02-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Nat Commun, 10, 2019
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7RLO
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![BU of 7rlo by Molmil](/molmil-images/mine/7rlo) | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs | Descriptor: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Wang, L, Schoof, M, Cogan, J, Lawrence, R, Boone, M, Wuerth, J, Frost, M, Walter, P. | Deposit date: | 2021-07-26 | Release date: | 2021-12-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun, 12, 2021
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