6CAJ

Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens

Summary for 6CAJ

• Entry DOI: 10.2210/pdb6caj/pdb
• Related: 6caj
• EMDB information: 7442 7443 7444
• Descriptor: Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit gamma, Translation initiation factor eIF-2B subunit alpha, ... (6 entities in total)
• Functional Keywords: guanine nucleotide exchange factor, translation initiation, isrib-bound, decameric complex, translation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 526770.76

Authors

Tsai, J.C.,Miller-Vedam, L.E.,Anand, A.A.,Jaishankar, P.,Nguyen, H.C.,Renslo, A.R.,Frost, A.,Walter, P. (deposition date: 2018-01-31, release date: 2018-04-11, Last modification date: 2019-11-20)

• Primary citation: Tsai, J.C.,Miller-Vedam, L.E.,Anand, A.A.,Jaishankar, P.,Nguyen, H.C.,Renslo, A.R.,Frost, A.,Walter, P.; Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.; Science, 359:-, 2018; PubMed: 29599213; DOI: 10.1126/science.aaq0939

Experimental method

ELECTRON MICROSCOPY (2.8 Å)