4N4P
| Crystal Structure of N-acetylneuraminate lyase from Mycoplasma synoviae, crystal form I | 分子名称: | Acylneuraminate lyase, CHLORIDE ION | 著者 | Georgescauld, F, Popova, K, Gupta, A.J, Bracher, A, Engen, J.R, Hayer-Hartl, M, Hartl, F.U. | 登録日 | 2013-10-08 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | GroEL/ES chaperonin modulates the mechanism and accelerates the rate of TIM-barrel domain folding. Cell(Cambridge,Mass.), 157, 2014
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4N4Q
| Crystal Structure of N-acetylneuraminate lyase from Mycoplasma synoviae, crystal form II | 分子名称: | Acylneuraminate lyase | 著者 | Georgescauld, F, Popova, K, Gupta, A.J, Bracher, A, Engen, J.R, Hayer-Hartl, M, Hartl, F.U. | 登録日 | 2013-10-08 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding. Cell(Cambridge,Mass.), 157, 2014
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3FZU
| IgG1 Fab characterized by H/D exchange | 分子名称: | immunoglobulin IgG1 Fab, heavy chain, light chain | 著者 | Arndt, J, Houde, D, Domeier, W, Berkowitz, S, Engen, J.R. | 登録日 | 2009-01-26 | 公開日 | 2009-03-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal Chem, 81, 2009
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6OA9
| Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ... | 著者 | Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A. | 登録日 | 2019-03-15 | 公開日 | 2019-07-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science, 365, 2019
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6OAA
| Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ... | 著者 | Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A. | 登録日 | 2019-03-15 | 公開日 | 2019-07-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science, 365, 2019
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6OAB
| Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ... | 著者 | Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A. | 登録日 | 2019-03-15 | 公開日 | 2019-07-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science, 365, 2019
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6QA2
| R80A MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS | 分子名称: | Nucleoside diphosphate kinase, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE | 著者 | Dautant, A, Henri, J, Wales, T.E, Meyer, P, Engen, J.R, Georgescauld, F. | 登録日 | 2018-12-18 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange. Biochemistry, 58, 2019
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5NV3
| Structure of Rubisco from Rhodobacter sphaeroides in complex with CABP | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Ribulose bisphosphate carboxylase large chain, ... | 著者 | Bracher, A, Milicic, G, Ciniawsky, S, Wendler, P, Hayer-Hartl, M, Hartl, F.U. | 登録日 | 2017-05-03 | 公開日 | 2017-07-26 | 最終更新日 | 2017-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Mechanism of Enzyme Repair by the AAA(+) Chaperone Rubisco Activase. Mol. Cell, 67, 2017
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6YHR
| Crystal structure of Werner syndrome helicase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Werner syndrome ATP-dependent helicase, ZINC ION | 著者 | Newman, J.A, Gavard, A.E, Savitsky, P, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | 登録日 | 2020-03-30 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Life Sci Alliance, 4, 2021
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8GMB
| Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible) | 分子名称: | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK | 著者 | Lin, D.Y, Andreotti, A.H. | 登録日 | 2023-03-24 | 公開日 | 2023-08-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
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8S9F
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8S93
| Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase | 分子名称: | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ... | 著者 | Lin, D.Y, Andreotti, A.H. | 登録日 | 2023-03-27 | 公開日 | 2023-08-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
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7UY0
| Crystal structure of human Fgr tyrosine kinase in complex with A-419259 | 分子名称: | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ... | 著者 | Du, S, Alvarado, J.J, Smithgall, T.E. | 登録日 | 2022-05-06 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 2022
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7UY3
| Crystal structure of human Fgr tyrosine kinase in complex with TL02-59 | 分子名称: | 1,2-ETHANEDIOL, 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, ... | 著者 | Du, S, Alvarado, J.J, Smithgall, T.E. | 登録日 | 2022-05-06 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 2022
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6CHS
| Cdc48-Npl4 complex in the presence of ATP-gamma-S | 分子名称: | MAGNESIUM ION, Npl4, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Kim, K.H, Bodnar, N.O, Walz, T, Rapoport, T.A. | 登録日 | 2018-02-22 | 公開日 | 2018-07-04 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nat. Struct. Mol. Biol., 25, 2018
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6DBS
| Fusion surface structure, function, and dynamics of gamete fusogen HAP2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hapless 2, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Feng, J, Dong, X, Springer, T.A. | 登録日 | 2018-05-03 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Fusion surface structure, function, and dynamics of gamete fusogen HAP2. Elife, 7, 2018
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6BOF
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6CDD
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3MXO
| Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Chaikuad, A, Alfano, I, Picaud, S, Filippakopoulos, P, Barr, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Takeda, K, Ichijo, H, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-05-07 | 公開日 | 2010-09-15 | 最終更新日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly. Structure, 25, 2017
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3O0T
| Crystal structure of human phosphoglycerate mutase family member 5 (PGAM5) in complex with phosphate | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, Serine/threonine-protein phosphatase PGAM5, ... | 著者 | Chaikuad, A, Alfano, I, Picaud, S, Filippakopoulos, P, Barr, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Takeda, K, Ichijo, H, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-07-20 | 公開日 | 2010-10-06 | 最終更新日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly. Structure, 25, 2017
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3UWP
| Crystal structure of Dot1l in complex with 5-iodotubercidin | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | 著者 | Yu, W, Tempel, W, Smil, D, Schapira, M, Li, Y, Vedadi, M, Nguyen, K.T, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2011-12-02 | 公開日 | 2012-03-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun, 3, 2012
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3V79
| Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence | 分子名称: | DNA 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', DNA 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ... | 著者 | Nam, Y, Sliz, P, Blacklow, S. | 登録日 | 2011-12-20 | 公開日 | 2012-02-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.85 Å) | 主引用文献 | Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes. Structure, 20, 2012
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5MW6
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5MWD
| Crystal structure of the BCL6 BTB-domain with compound 2 | 分子名称: | 5-[[5-chloranyl-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]amino]-1,3-dihydroindol-2-one, B-cell lymphoma 6 protein | 著者 | Bader, G, Flotzinger, G, Weiss-Puxbaum, A, Zoephel, A. | 登録日 | 2017-01-18 | 公開日 | 2017-10-04 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep, 20, 2017
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5MUF
| Crystal structure of human phosphoglycerate mutase family member 5 (PGAM5) in its enzymatically active dodecameric form induced by the presence of the N-terminal WDPNWD motif | 分子名称: | PHOSPHATE ION, Serine/threonine-protein phosphatase PGAM5, mitochondrial | 著者 | Chaikuad, A, Alfano, I, Picaud, S, Filippakopoulos, P, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2017-01-13 | 公開日 | 2017-07-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly. Structure, 25, 2017
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