5MUF

Crystal structure of human phosphoglycerate mutase family member 5 (PGAM5) in its enzymatically active dodecameric form induced by the presence of the N-terminal WDPNWD motif

Summary for 5MUF

• Entry DOI: 10.2210/pdb5muf/pdb
• Related: 3MXO 3O0T
• Descriptor: Serine/threonine-protein phosphatase PGAM5, mitochondrial, PHOSPHATE ION (3 entities in total)
• Functional Keywords: phosphoglycerate mutase family member 5, pgam5, serine/threonine phosphatase, mitochondrial protein, hydrolase, wdpnwd motif, wdxnwd motif, dimer, dodecamer, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion outer membrane ; Single-pass membrane protein : Q96HS1
• Total number of polymer chains: 3
• Total formula weight: 81701.60

Authors

Chaikuad, A.,Alfano, I.,Picaud, S.,Filippakopoulos, P.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-13, release date: 2017-07-12, Last modification date: 2024-01-17)

• Primary citation: Chaikuad, A.,Filippakopoulos, P.,Marcsisin, S.R.,Picaud, S.,Schroder, M.,Sekine, S.,Ichijo, H.,Engen, J.R.,Takeda, K.,Knapp, S.; Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.; Structure, 25:1089-1099.e3, 2017; PubMed: 28648608; DOI: 10.1016/j.str.2017.05.020

Experimental method

X-RAY DIFFRACTION (3.1 Å)