8S9F

Crystal structure of the kinase domain of Bruton's Tyrosine Kinase bound to dasatinib

Summary for 8S9F

Entry DOI	10.2210/pdb8s9f/pdb
Related	8GMB 8S93
Descriptor	Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total)
Functional Keywords	bruton's tyrosine kinase, atp-binding, protein phosphorylation, transferase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	65548.00
Authors	Lin, D.Y.,Andreotti, A.H. (deposition date: 2023-03-28, release date: 2023-08-16, Last modification date: 2024-01-31)
Primary citation	Lin, D.Y.,Kueffer, L.E.,Juneja, P.,Wales, T.E.,Engen, J.R.,Andreotti, A.H. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12:-, 2024 Cited by PubMed: 38189455 DOI: 10.7554/eLife.89489 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation