8S9F
Crystal structure of the kinase domain of Bruton's Tyrosine Kinase bound to dasatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Tyrosine-protein kinase BTK | polymer | 279 | 32286.0 | 2 | UniProt (P35991) Pfam (PF07714) | Mus musculus (house mouse) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase,Kinase EMB |
| 2 | C, D (B, A) | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | non-polymer | 488.0 | 2 | Chemie (1N1) | |||
| 3 | E, F (B, A) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
B, A: 382 - 659 (UniProt: P35991)
| PDB | External Database | Details |
|---|---|---|
| Met 381 | - | initiating methionine |
| Gly 390 | Leu 390 | engineered mutation |
| Glu 551 | Tyr 551 | engineered mutation |
| Pro 617 | Tyr 617 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64572.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 976.0 | |
| All* | Total formula weight | 65548.0 |
