4M6W
| Crystal structure of the C-terminal segment of FANCM in complex with FAAP24 | 分子名称: | Fanconi anemia group M protein, Fanconi anemia-associated protein of 24 kDa, SULFATE ION | 著者 | Yang, H, Zhang, T, Tong, L, Ding, J. | 登録日 | 2013-08-11 | 公開日 | 2013-10-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. Nucleic Acids Res., 41, 2013
|
|
7WR1
| P32 of caspase-4 C258A mutant in complex with OspC3 C-terminal ankyrin-repeat domain | 分子名称: | Caspase-4, OspC3 | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
|
|
7WR4
| Crystal structure of OspC3-calmodulin-caspase-4 complex | 分子名称: | Calmodulin-1, Caspase-4, OspC3 | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
|
|
7WR0
| P32 of caspase-4 C258A mutant | 分子名称: | Caspase-4 | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
|
|
7WR6
| Crystal structure of ADP-riboxanated caspase-4 in complex with Af1521 | 分子名称: | ADP-ribose glycohydrolase AF_1521, Caspase-4, [[(3~{a}~{S},5~{R},6~{R},6~{a}~{R})-2-azanylidene-3-[(4~{R})-4-azanyl-5-oxidanylidene-pentyl]-6-oxidanyl-3~{a},5,6,6~{a}-tetrahydrofuro[2,3-d][1,3]oxazol-5-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
|
|
7WR3
| Crystal structure of MBP-fused OspC3 in complex with calmodulin | 分子名称: | Calmodulin-1, MBP-fused OspC3, NICOTINAMIDE, ... | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
|
|
7WR2
| |
7WR5
| Crystal structure of OspC3-calmodulin-caspase-4 complex binding with 2'-aF-NAD+ | 分子名称: | Calmodulin-1, Caspase-4, OspC3, ... | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
|
|
5Y38
| Crystal structure of C7orf59-HBXIP complex | 分子名称: | Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5, SULFATE ION | 著者 | Zhang, T, Ding, J. | 登録日 | 2017-07-28 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun, 8, 2017
|
|
5Y39
| Crystal structure of Ragulator complex (p18 76-145) | 分子名称: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | 著者 | Zhang, T, Ding, J. | 登録日 | 2017-07-28 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun, 8, 2017
|
|
5Y3A
| Crystal structure of Ragulator complex (p18 49-161) | 分子名称: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | 著者 | Zhang, T, Ding, J. | 登録日 | 2017-07-28 | 公開日 | 2017-12-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1. Nat Commun, 8, 2017
|
|
6E66
| |
8F1G
| Crystal structure of human WDR5 in complex with compound WM662 | 分子名称: | (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... | 著者 | Liu, H. | 登録日 | 2022-11-05 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
|
|
1WAV
| CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN | 分子名称: | INSULIN, PHENOL, ZINC ION | 著者 | Liang, D.-C, Ding, J.-H, Chang, W.-R, Wan, Z.-L. | 登録日 | 1996-02-28 | 公開日 | 1997-02-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular replacement study on form-B monoclinic crystal of insulin. Sci.China, Ser.C: Life Sci., 39, 1996
|
|
8G3C
| |
8G3E
| Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor) | 分子名称: | (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5 | 著者 | Zhao, M. | 登録日 | 2023-02-07 | 公開日 | 2023-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
|
|
1HJA
| |
8FW4
| |
6V97
| Kindlin-3 double deletion mutant short form | 分子名称: | Fermitin family homolog 3 | 著者 | Xu, Z, Zhang, T.L, Xu, Z, Sun, J.J, Ding, J.P, Ma, Y.Q. | 登録日 | 2019-12-13 | 公開日 | 2020-07-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.381 Å) | 主引用文献 | Structure basis of the FERM domain of kindlin-3 in supporting integrin alpha IIb beta 3 activation in platelets. Blood Adv, 4, 2020
|
|
6V9G
| Kindlin-3 double deletion mutant long form | 分子名称: | Fermitin family homolog 3 | 著者 | Xu, Z, Zhang, T.L, Xu, Z, Sun, J.J, Ding, J.P, Ma, Y.Q. | 登録日 | 2019-12-13 | 公開日 | 2020-07-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structure basis of the FERM domain of kindlin-3 in supporting integrin alpha IIb beta 3 activation in platelets. Blood Adv, 4, 2020
|
|
6YF1
| FKBP12 in complex with the BMP potentiator compound 8 at 1.12A resolution | 分子名称: | (1aR,3R,5S,6R,7S,9R,10R,17aS,20S,21R,22S,25R,25aR)-25-Ethyl-10,22-dihydroxy-20-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-5,7-dimethoxy-1a,3,9,21-tetramethyloctadecahydro-2H-6,10-epoxyoxireno[p]pyrido[2,1-c][1,4]oxazacyclotricosine-11,12,18,24(1aH,14H)-tetrone, Peptidyl-prolyl cis-trans isomerase FKBP1A | 著者 | Kallen, J. | 登録日 | 2020-03-25 | 公開日 | 2021-03-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chem Biol, 28, 2021
|
|
6YF2
| FKBP12 in complex with the BMP potentiator compound 6 at 1.03A resolution | 分子名称: | (1~{R},9~{S},12~{S},13~{R},14~{S},17~{R},18~{E},21~{S},23~{S},24~{R},25~{S},27~{R})-23,25-dimethoxy-12-[(~{E})-1-[(1~{R},3~{R},4~{R})-3-methoxy-4-oxidanyl-cyclohexyl]prop-1-en-2-yl]-13,19,21,27-tetramethyl-1,14-bis(oxidanyl)-17-(2-oxidanylidenepropyl)-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone, CADMIUM ION, CHLORIDE ION, ... | 著者 | Kallen, J. | 登録日 | 2020-03-25 | 公開日 | 2021-03-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chem Biol, 28, 2021
|
|
6YF0
| |
6YF3
| FKBP12 in complex with the BMP potentiator compound 10 at 1.00A resolution | 分子名称: | (1~{R},9~{S},12~{S},13~{R},14~{S},17~{R},18~{E},21~{S},23~{S},24~{R},25~{S},27~{R})-17-ethyl-25-methoxy-12-[(~{E})-1-[(1~{R},3~{R},4~{R})-3-methoxy-4-oxidanyl-cyclohexyl]prop-1-en-2-yl]-13,19,21,27-tetramethyl-1,14,23-tris(oxidanyl)-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone, CADMIUM ION, CHLORIDE ION, ... | 著者 | Kallen, J. | 登録日 | 2020-03-25 | 公開日 | 2021-03-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chem Biol, 28, 2021
|
|
4XHR
| Structure of a phospholipid trafficking complex, native | 分子名称: | Mitochondrial distribution and morphology protein 35, Protein UPS1, mitochondrial | 著者 | Yu, F, He, F, Wang, C, Zhang, P. | 登録日 | 2015-01-06 | 公開日 | 2015-07-01 | 最終更新日 | 2015-08-05 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex Embo Rep., 16, 2015
|
|