6YF2

FKBP12 in complex with the BMP potentiator compound 6 at 1.03A resolution

Summary for 6YF2

Entry DOI	10.2210/pdb6yf2/pdb
Related	6YF0 6YF1
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP1A, (1~{R},9~{S},12~{S},13~{R},14~{S},17~{R},18~{E},21~{S},23~{S},24~{R},25~{S},27~{R})-23,25-dimethoxy-12-[(~{E})-1-[(1~{R},3~{R},4~{R})-3-methoxy-4-oxidanyl-cyclohexyl]prop-1-en-2-yl]-13,19,21,27-tetramethyl-1,14-bis(oxidanyl)-17-(2-oxidanylidenepropyl)-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone, CADMIUM ION, ... (6 entities in total)
Functional Keywords	immunosuppression, immunosuppressant, bmp enhancer program, isomerase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13017.00
Authors	Kallen, J. (deposition date: 2020-03-25, release date: 2021-03-10, Last modification date: 2024-01-24)
Primary citation	Larraufie, M.H.,Gao, X.,Xia, X.,Devine, P.J.,Kallen, J.,Liu, D.,Michaud, G.,Harsch, A.,Savage, N.,Ding, J.,Tan, K.,Mihalic, M.,Roggo, S.,Canham, S.M.,Bushell, S.M.,Krastel, P.,Gao, J.,Izaac, A.,Altinoglu, E.,Lustenberger, P.,Salcius, M.,Harbinski, F.,Williams, E.T.,Zeng, L.,Loureiro, J.,Cong, F.,Fryer, C.J.,Klickstein, L.,Tallarico, J.A.,Jain, R.K.,Rothman, D.M.,Wang, S. Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. Cell Chem Biol, 28:1271-, 2021 Cited by PubMed: 33894161 DOI: 10.1016/j.chembiol.2021.04.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.03 Å)

Structure validation