6YF2
FKBP12 in complex with the BMP potentiator compound 6 at 1.03A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 109 | 11990.7 | 1 | UniProt (P62942) Pfam (PF00254) In PDB | Homo sapiens (Human) | PPIase FKBP1A,12 kDa FK506-binding protein,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase |
| 2 | A | (1~{R},9~{S},12~{S},13~{R},14~{S},17~{R},18~{E},21~{S},23~{S},24~{R},25~{S},27~{R})-23,25-dimethoxy-12-[(~{E})-1-[(1~{R},3~{R},4~{R})-3-methoxy-4-oxidanyl-cyclohexyl]prop-1-en-2-yl]-13,19,21,27-tetramethyl-1,14-bis(oxidanyl)-17-(2-oxidanylidenepropyl)-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone | non-polymer | 820.0 | 1 | Chemie (OP5) | |||
| 3 | A | CADMIUM ION | non-polymer | 112.4 | 1 | Chemie (CD) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 1 - 107 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11990.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1026.3 | |
| All* | Total formula weight | 13017.0 |
