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6YF2

FKBP12 in complex with the BMP potentiator compound 6 at 1.03A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0003007biological_processheart morphogenesis
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005515molecular_functionprotein binding
A0005527molecular_functionmacrolide binding
A0005528molecular_functionFK506 binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006457biological_processprotein folding
A0006458biological_process'de novo' protein folding
A0014802cellular_componentterminal cisterna
A0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016247molecular_functionchannel regulator activity
A0016529cellular_componentsarcoplasmic reticulum
A0022417biological_processprotein maturation by protein folding
A0030018cellular_componentZ disc
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0030547molecular_functionsignaling receptor inhibitor activity
A0032092biological_processpositive regulation of protein binding
A0032880biological_processregulation of protein localization
A0032926biological_processnegative regulation of activin receptor signaling pathway
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0042026biological_processprotein refolding
A0042110biological_processT cell activation
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0050776biological_processregulation of immune response
A0055010biological_processventricular cardiac muscle tissue morphogenesis
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060347biological_processheart trabecula formation
A0070411molecular_functionI-SMAD binding
A0070588biological_processcalcium ion transmembrane transport
A0070697molecular_functionactivin receptor binding
A0097435biological_processsupramolecular fiber organization
A0098562cellular_componentcytoplasmic side of membrane
A1902991biological_processregulation of amyloid precursor protein catabolic process
A1990000biological_processamyloid fibril formation
A1990425cellular_componentryanodine receptor complex
Functional Information from PDB Data
site_idAC1
Number of Residues29
Detailsbinding site for residue OP5 A 201
ChainResidue
ATYR26
AALA81
ATYR82
ATYR82
ATHR85
AGLY86
AHIS87
AHIS87
APRO88
APRO88
AILE90
APHE36
AILE91
APHE99
AHOH333
AHOH371
AHOH378
AHOH378
AHOH381
AHOH381
AHOH391
AHOH429
AASP37
AARG42
APHE46
AGLU54
AVAL55
AILE56
ATRP59

site_idAC2
Number of Residues6
Detailsbinding site for residue CD A 202
ChainResidue
AGLU54
ACL203
ACL203
ACL204
AHOH350
AHOH411

site_idAC3
Number of Residues6
Detailsbinding site for residue CL A 203
ChainResidue
ALYS52
ALYS52
AGLU54
AGLU54
ACD202
ACD202

site_idAC4
Number of Residues3
Detailsbinding site for residue CL A 204
ChainResidue
APHE48
ALYS52
ACD202

site_idAC5
Number of Residues4
Detailsbinding site for residue NA A 205
ChainResidue
AGLU54
AGLU54
AHOH437
AHOH437

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883
ChainResidueDetails
ALYS52

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
ATYR26electrostatic destabiliser, steric role
APHE36electrostatic destabiliser, polar/non-polar interaction, steric role
AASP37electrostatic stabiliser, steric role
AILE56electrostatic stabiliser, steric role
ATYR82electrostatic stabiliser, steric role
APHE99electrostatic destabiliser, polar/non-polar interaction, steric role

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PDB entries from 2024-05-22

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