8G3C

Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor)

Summary for 8G3C

Entry DOI	10.2210/pdb8g3c/pdb
Descriptor	WD repeat-containing protein 5, N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (3 entities in total)
Functional Keywords	wdr5, wbm, myc, small molecule, oncoprotein-inhibitor complex, oncoprotein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34751.35
Authors	Zhao, M. (deposition date: 2023-02-07, release date: 2023-06-28, Last modification date: 2023-10-25)
Primary citation	Ding, J.,Liu, L.,Chiang, Y.L.,Zhao, M.,Liu, H.,Yang, F.,Shen, L.,Lin, Y.,Deng, H.,Gao, J.,Sage, D.R.,West, L.,Llamas, L.A.,Hao, X.,Kawatkar, S.,Li, E.,Jain, R.K.,Tallarico, J.A.,Canham, S.M.,Wang, H. Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66:8310-8323, 2023 Cited by PubMed: 37307526 DOI: 10.1021/acs.jmedchem.3c00787 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation