5YWP
| JEV-2H4 Fab complex | 分子名称: | 2H4 heavy chain, 2H4 light chain, JEV E protein, ... | 著者 | Qiu, X.D, Lei, Y.F, Yang, P, Gao, Q, WANG, N, Cao, L, Yuan, S, Wang, X.X, Xu, Z.K, Rao, Z.H. | 登録日 | 2017-11-29 | 公開日 | 2018-05-02 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies Nat Microbiol, 3, 2018
|
|
7WED
| |
7WLC
| |
7WEC
| |
7WE7
| SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv282 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 282, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2021-12-23 | 公開日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature, 603, 2022
|
|
7WEF
| |
7WE8
| SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 265, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2021-12-23 | 公開日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature, 603, 2022
|
|
7WEA
| |
7WEE
| |
7WEB
| |
7WE9
| |
6B3W
| Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | 分子名称: | 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of zeste 2 polycomb repressive complex 2 subunit,Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, ... | 著者 | Gajiwala, K.S, Brooun, A, Liu, W, Deng, Y, Stewart, A.E. | 登録日 | 2017-09-25 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J. Med. Chem., 61, 2018
|
|
7Y67
| Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein | 分子名称: | C089 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2022-06-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
|
|
7Y64
| Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | 分子名称: | C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2022-06-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
|
|
7Y65
| Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein | 分子名称: | C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2022-06-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
|
|
7Y66
| Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein | 分子名称: | BM213 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2022-06-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
|
|
8FS1
| CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11a (YD905) | 分子名称: | 1,2-ETHANEDIOL, 5'-S-{2-[N'-(cyclohexylmethyl)carbamimidamido]ethyl}-N-(3-phenylpropyl)-5'-thioadenosine, DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), ... | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-01-09 | 公開日 | 2023-05-10 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase. Acs Chem.Biol., 18, 2023
|
|
8FS2
| CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11b (YD907) | 分子名称: | 1,2-ETHANEDIOL, 5'-S-{3-[N'-(cyclohexylmethyl)carbamimidamido]propyl}-N-(3-phenylpropyl)-5'-thioadenosine, DNA (5'-D(*TP*TP*CP*AP*AP*AP*AP*AP*GP*TP*CP*CP*CP*A)-3'), ... | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-01-09 | 公開日 | 2023-05-10 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase. Acs Chem.Biol., 18, 2023
|
|
8IIB
| Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta85 mutant (residues 86-546) | 分子名称: | CADMIUM ION, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Fang, X, Lu, G, Hou, C, Gong, P. | 登録日 | 2023-02-24 | 公開日 | 2023-06-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
|
|
8IIC
| |
7VBS
| |
7VBW
| |
7F7H
| SARS-CoV-2 S protein RBD in complex with A8-1 Fab | 分子名称: | Heavy chain of A8-1 Fab, Light chain of A8-1 Fab, Spike glycoprotein S1 | 著者 | Dou, Y, Wang, X, Wang, K, Liu, P, Lu, B. | 登録日 | 2021-06-29 | 公開日 | 2022-06-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | High throughput isolation of potent neutralizing antibodies from convalescent COVID-19 patients. To Be Published
|
|
5XQ1
| Structural basis of kindlin-mediated integrin recognition and activation | 分子名称: | Fermitin family homolog 2,Integrin beta-3 | 著者 | Li, H, Yang, H, Sun, K, Zhang, Z, Yu, C, Wei, Z. | 登録日 | 2017-06-05 | 公開日 | 2017-07-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.954 Å) | 主引用文献 | Structural basis of kindlin-mediated integrin recognition and activation Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5XPZ
| Structural basis of kindlin-mediated integrin recognition and activation | 分子名称: | Fermitin family homolog 2, GLYCEROL | 著者 | Li, H, Yang, H, Sun, K, Zhang, Z, Yu, C, Wei, Z. | 登録日 | 2017-06-05 | 公開日 | 2017-07-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Structural basis of kindlin-mediated integrin recognition and activation Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|