8FS1

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11a (YD905)

Summary for 8FS1

• Entry DOI: 10.2210/pdb8fs1/pdb
• Descriptor: Site-specific DNA-methyltransferase (adenine-specific), DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: dna adenine methylation, protein-dna complex, transferase, dna binding protein, transferase-dna-inhibitor complex, transferase/dna/inhibitor
• Biological source: Clostridioides difficile; More
• Total number of polymer chains: 9
• Total formula weight: 234457.57

Authors

Zhou, J.,Horton, J.R.,Cheng, X. (deposition date: 2023-01-09, release date: 2023-05-10, Last modification date: 2023-05-17)

• Primary citation: Zhou, J.,Deng, Y.,Iyamu, I.D.,Horton, J.R.,Yu, D.,Hajian, T.,Vedadi, M.,Rotili, D.,Mai, A.,Blumenthal, R.M.,Zhang, X.,Huang, R.,Cheng, X.; Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase.; Acs Chem.Biol., 18:734-745, 2023; PubMed: 37082867; DOI: 10.1021/acschembio.3c00035

Experimental method

X-RAY DIFFRACTION (2.74 Å)