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6JYP
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BU of 6jyp by Molmil
Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide
分子名称: 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-04-27
公開日2020-05-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献uPA-HMA
To Be Published
6JYQ
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BU of 6jyq by Molmil
Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide
分子名称: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-04-27
公開日2020-05-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献H99Y-6F-HMA-pH7
To Be Published
6L05
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BU of 6l05 by Molmil
Crystal structure of uPA_H99Y in complex with 50F
分子名称: 3-azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-09-26
公開日2020-09-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Crystal structure of uPA_H99Y in complex with 50F
To Be Published
6L04
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BU of 6l04 by Molmil
Crystal structure of uPA_H99Y in complex with 31F
分子名称: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-09-26
公開日2020-09-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal structure of uPA_H99Y in complex with 31F
To Be Published
6AG7
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BU of 6ag7 by Molmil
The crystal structure of uPA in complex with HMA-55F
分子名称: 3,5-diamino-N-carbamimidoyl-6-(1-methyl-1H-pyrazol-4-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Majed, H, Huang, M.D, Kelso, M, Ranson, M.
登録日2018-08-09
公開日2019-08-14
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献uPA-HMA
To Be Published
6AG3
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BU of 6ag3 by Molmil
Crystal structure of uPA in complex with 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide
分子名称: 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Majed, H, Huang, M.D, Kelso, M, Ranson, M.
登録日2018-08-09
公開日2019-09-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献uPA-HMA
To Be Published
6AG9
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BU of 6ag9 by Molmil
Crystal structure of uPA in complex with 3,5-bis(azanyl)-6-(1-benzofuran-2-yl)-N-carbamimidoyl-pyrazine-2- carboxamide
分子名称: 3,5-bis(azanyl)-6-(1-benzofuran-2-yl)-N-carbamimidoyl-pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Majed, H, Huang, M.D, Kelso, M, Ranson, M.
登録日2018-08-09
公開日2019-09-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献uPA-HMA
To Be Published
6AG2
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BU of 6ag2 by Molmil
uPA-HMA
分子名称: 3,5-bis(azanyl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2018-08-09
公開日2019-09-18
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献uPA-HMA
To Be Published
1A6C
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BU of 1a6c by Molmil
STRUCTURE OF TOBACCO RINGSPOT VIRUS
分子名称: TOBACCO RINGSPOT VIRUS CAPSID PROTEIN
著者Johnson, J.E, Chandrasekar, V.
登録日1998-02-23
公開日1998-07-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献The structure of tobacco ringspot virus: a link in the evolution of icosahedral capsids in the picornavirus superfamily.
Structure, 6, 1998
8FV4
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BU of 8fv4 by Molmil
EGFR(T790M/V948R) in complex with compound 2 (LN5993)
分子名称: Epidermal growth factor receptor, MAGNESIUM ION, N-{(3P)-3-[(4P)-4-(2-acetamidopyridin-4-yl)-2-(methylsulfanyl)-1H-imidazol-5-yl]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-9-carboxamide, ...
著者Ogboo, B.C, Beyett, T.S, Eck, M.J, Heppner, D.E.
登録日2023-01-18
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
Commun Chem, 7, 2024
8FV3
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BU of 8fv3 by Molmil
EGFR(T790M/V948R) in complex with compound 1 (LN4503)
分子名称: Epidermal growth factor receptor, MAGNESIUM ION, N-{(4P)-4-[(4P)-5-{3-[(8-fluoro-11-oxo-5,11-dihydro-10H-dibenzo[b,e][1,4]diazepin-10-yl)methyl]phenyl}-2-(methylsulfanyl)-1H-imidazol-4-yl]pyridin-2-yl}acetamide, ...
著者Ogboo, B.C, Heppner, D.E.
登録日2023-01-18
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
Commun Chem, 7, 2024
7UKV
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BU of 7ukv by Molmil
Wild type EGFR in complex with Lazertinib (YH25448)
分子名称: Epidermal growth factor receptor, N-[5-{[(4P)-4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl]amino}-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide
著者Beyett, T.S, Pham, C, Eck, M.J, Heppner, D.E.
登録日2022-04-02
公開日2022-11-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
Acs Med.Chem.Lett., 13, 2022
7UKW
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BU of 7ukw by Molmil
EGFR(T790M/V948R) in complex with Lazertinib (YH25448)
分子名称: Epidermal growth factor receptor, N-[5-{[(4P)-4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl]amino}-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide
著者Pham, C.D, Heppner, D.E.
登録日2022-04-02
公開日2022-11-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
Acs Med.Chem.Lett., 13, 2022
5D4D
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BU of 5d4d by Molmil
Crystal structure of Thermus thermophilus product complex for transcription initiation with NAD and CTP
分子名称: ADENOSINE-5'-MONOPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Zhang, Y, Ebright, R.H.
登録日2015-08-07
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Nature, 535, 2016
5D4C
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BU of 5d4c by Molmil
Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Zhang, Y, Ebright, R.H.
登録日2015-08-07
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.28 Å)
主引用文献The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Nature, 535, 2016
5D4E
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BU of 5d4e by Molmil
Crystal structure of Thermus thermophilus product complex for transcription initiation with 3'-dephosphate-CoA and CTP
分子名称: CYTIDINE-5'-MONOPHOSPHATE, DEPHOSPHO COENZYME A, DIPHOSPHATE, ...
著者Zhang, Y, Ebright, R.H.
登録日2015-08-07
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Nature, 535, 2016

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件を2024-04-24に公開中

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