7UKW
EGFR(T790M/V948R) in complex with Lazertinib (YH25448)
Summary for 7UKW
| Entry DOI | 10.2210/pdb7ukw/pdb |
| Descriptor | Epidermal growth factor receptor, N-[5-{[(4P)-4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl]amino}-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide (3 entities in total) |
| Functional Keywords | cancer, drug design, egfr, signal transduction, targeted therapy, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 4 |
| Total formula weight | 151030.79 |
| Authors | Pham, C.D.,Heppner, D.E. (deposition date: 2022-04-02, release date: 2022-11-23, Last modification date: 2023-10-25) |
| Primary citation | Heppner, D.E.,Wittlinger, F.,Beyett, T.S.,Shaurova, T.,Urul, D.A.,Buckley, B.,Pham, C.D.,Schaeffner, I.K.,Yang, B.,Ogboo, B.C.,May, E.W.,Schaefer, E.M.,Eck, M.J.,Laufer, S.A.,Hershberger, P.A. Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448). Acs Med.Chem.Lett., 13:1856-1863, 2022 Cited by PubMed: 36518696DOI: 10.1021/acsmedchemlett.2c00213 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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