6N3C
 
 | | SegB, conformation of TDP-43 low complexity domain segment A | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2018-11-14 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
Nat.Struct.Mol.Biol., 26, 2019
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6N3B
 | | SegA-asym, conformation of TDP-43 low complexity domain segment A asym | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2018-11-14 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
Nat.Struct.Mol.Biol., 26, 2019
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6NB9
 | | Amyloid-Beta (20-34) with L-isoaspartate 23 | | 分子名称: | Amyloid-beta A4 protein | | 著者 | Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. | | 登録日 | 2018-12-06 | | 公開日 | 2019-08-07 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | | 主引用文献 | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
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7M64
 | | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3 | | 分子名称: | Islet amyloid polypeptide | | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2021-03-25 | | 公開日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
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7M65
 | | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4 | | 分子名称: | Islet amyloid polypeptide | | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2021-03-25 | | 公開日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
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7M62
 | | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2 | | 分子名称: | Islet amyloid polypeptide | | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2021-03-25 | | 公開日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
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7M61
 | | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 1 | | 分子名称: | Islet amyloid polypeptide | | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2021-03-25 | | 公開日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
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5V5B
 | | KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2 | | 分子名称: | Microtubule-associated protein tau | | 著者 | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | | 登録日 | 2017-03-13 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | | 主引用文献 | Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
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5V5C
 | | VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2 | | 分子名称: | Microtubule-associated protein tau | | 著者 | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | | 登録日 | 2017-03-14 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.25 Å) | | 主引用文献 | Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
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8FQ7
 | | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | | 分子名称: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | | 著者 | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | | 登録日 | 2023-01-05 | | 公開日 | 2023-10-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6OIZ
 | | Amyloid-Beta (20-34) wild type | | 分子名称: | Amyloid beta A4 protein | | 著者 | Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S. | | 登録日 | 2019-04-10 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | | 主引用文献 | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
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6CU7
 | | Alpha Synuclein fibril formed by full length protein - Rod Polymorph | | 分子名称: | Alpha-synuclein | | 著者 | Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L. | | 登録日 | 2018-03-23 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.
Nat Commun, 9, 2018
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6CFH
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6CB9
 | | Segment AALQSS from the low complexity domain of TDP-43, residues 328-333 | | 分子名称: | AALQSS | | 著者 | Guenther, E.L, Cao, Q, Lu, J, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2018-02-02 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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6CEW
 | | Segment AMMAAA from the low complexity domain of TDP-43, residues 321-326 | | 分子名称: | AMMAAA | | 著者 | Guenther, E.L, Cao, Q, Lu, J, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2018-02-12 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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6CU8
 | | Alpha Synuclein fibril formed by full length protein - Twister Polymorph | | 分子名称: | Alpha-synuclein | | 著者 | Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L. | | 登録日 | 2018-03-23 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.
Nat Commun, 9, 2018
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5WKB
 | | MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2017-07-24 | | 公開日 | 2018-05-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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6BWZ
 | | SYSGYS from low-complexity domain of FUS, residues 37-42 | | 分子名称: | SYSGYS peptide from low-complexity domain of FUS | | 著者 | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Tamir, G, Eisenberg, D.S. | | 登録日 | 2017-12-15 | | 公開日 | 2018-04-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6BZP
 | | STGGYG from low-complexity domain of FUS, residues 77-82 | | 分子名称: | 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, RNA-binding protein FUS | | 著者 | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S. | | 登録日 | 2017-12-25 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | | 主引用文献 | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6BXV
 | | SYSSYGQS from low-complexity domain of FUS, residues 54-61 | | 分子名称: | FUS | | 著者 | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S. | | 登録日 | 2017-12-19 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6BZM
 | | GFGNFGTS from low-complexity/FG repeat domain of Nup98, residues 116-123 | | 分子名称: | Nuclear pore complex protein Nup98-Nup96 | | 著者 | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Chong, L, Gonen, T, Eisenberg, D.S. | | 登録日 | 2017-12-24 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | | 主引用文献 | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6BXX
 | | GYNGFG from low-complexity domain of hnRNPA1, residues 243-248 | | 分子名称: | hnRNPA1 | | 著者 | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S. | | 登録日 | 2017-12-19 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6NK4
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7LTU
 | | AALALL SEGMENT FROM THE NUCLEOPROTEIN OF SARS-COV-2, RESIDUES 217-222, CRYSTAL FORM 1 | | 分子名称: | AALALL SEGMENT FROM THE NUCLEOPROTEIN OF SARS-COV-2,RESIDUES 217-222, trifluoroacetic acid | | 著者 | Zee, C.-T, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S. | | 登録日 | 2021-02-20 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.122 Å) | | 主引用文献 | Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
Biorxiv, 2021
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7LUX
 | | AALALL segment from the Nucleoprotein of SARS-CoV-2, residues 217-222, crystal form 2 | | 分子名称: | Nucleoprotein AALALL, TETRAETHYLENE GLYCOL | | 著者 | Lu, J, Zee, C.-T, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S. | | 登録日 | 2021-02-23 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.303 Å) | | 主引用文献 | Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
Biorxiv, 2021
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