1BGW
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![BU of 1bgw by Molmil](/molmil-images/mine/1bgw) | TOPOISOMERASE RESIDUES 410-1202, | Descriptor: | TOPOISOMERASE | Authors: | Berger, J.M, Gamblin, S.J, Harrison, S.C, Wang, J.C. | Deposit date: | 1996-02-20 | Release date: | 1996-07-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure and mechanism of DNA topoisomerase II. Nature, 379, 1996
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6DUQ
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![BU of 6duq by Molmil](/molmil-images/mine/6duq) | Structure of a Rho-NusG KOW domain complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Berger, J.M, Lawson, M.R. | Deposit date: | 2018-06-21 | Release date: | 2018-09-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein. Mol. Cell, 71, 2018
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2G2U
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![BU of 2g2u by Molmil](/molmil-images/mine/2g2u) | Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex | Descriptor: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein | Authors: | Reynolds, K.A, Thomson, J.M, Corbett, K.D, Bethel, C.R, Berger, J.M, Kirsch, J.F, Bonomo, R.A, Handel, T.M. | Deposit date: | 2006-02-16 | Release date: | 2006-07-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and Computational Characterization of the SHV-1 beta-Lactamase-beta-Lactamase Inhibitor Protein Interface. J.Biol.Chem., 281, 2006
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4GFH
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![BU of 4gfh by Molmil](/molmil-images/mine/4gfh) | Topoisomerase II-DNA-AMPPNP complex | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3'), ... | Authors: | Schmidt, B.H, Osheroff, N, Berger, J.M. | Deposit date: | 2012-08-03 | Release date: | 2012-10-03 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (4.408 Å) | Cite: | Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat.Struct.Mol.Biol., 19, 2012
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2RGR
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![BU of 2rgr by Molmil](/molmil-images/mine/2rgr) | Topoisomerase IIA bound to G-segment DNA | Descriptor: | DNA, DNA topoisomerase 2, MAGNESIUM ION | Authors: | Dong, K.C, Berger, J.M. | Deposit date: | 2007-10-04 | Release date: | 2007-12-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature, 450, 2007
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1MU5
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![BU of 1mu5 by Molmil](/molmil-images/mine/1mu5) | Structure of topoisomerase subunit | Descriptor: | CALCIUM ION, Type II DNA topoisomerase VI Subunit B | Authors: | Corbett, K.D, Berger, J.M. | Deposit date: | 2002-09-23 | Release date: | 2003-01-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution Embo J., 22, 2003
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1MX0
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![BU of 1mx0 by Molmil](/molmil-images/mine/1mx0) | Structure of topoisomerase subunit | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... | Authors: | Corbett, K.D, Berger, J.M. | Deposit date: | 2002-10-01 | Release date: | 2003-01-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution Embo J., 22, 2003
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8TXR
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![BU of 8txr by Molmil](/molmil-images/mine/8txr) | E. coli ExoVII(H238A) | Descriptor: | Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease 7 small subunit | Authors: | Liu, C, Berger, J.M. | Deposit date: | 2023-08-24 | Release date: | 2024-01-31 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of Escherichia coli exonuclease VII. Proc.Natl.Acad.Sci.USA, 121, 2024
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7UGW
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![BU of 7ugw by Molmil](/molmil-images/mine/7ugw) | M. tuberculosis DNA gyrase cleavage core bound to DNA and evybactin | Descriptor: | DNA (46-MER), DNA gyrase subunit A, DNA gyrase subunit B, ... | Authors: | Hauk, G, Imai, Y, Lewis, K, Berger, J.M. | Deposit date: | 2022-03-25 | Release date: | 2022-08-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis. Nat.Chem.Biol., 18, 2022
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7MU5
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![BU of 7mu5 by Molmil](/molmil-images/mine/7mu5) | Human DCTPP1 bound to Triptolide | Descriptor: | MAGNESIUM ION, dCTP pyrophosphatase 1, triptolide | Authors: | Hauk, G, Berger, J.M. | Deposit date: | 2021-05-14 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance To Be Published
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2G2W
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![BU of 2g2w by Molmil](/molmil-images/mine/2g2w) | Crystal Structure of the SHV D104K Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex | Descriptor: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein | Authors: | Reynolds, K.A, Thomson, J.M, Corbett, K.D, Bethel, C.R, Berger, J.M, Kirsch, J.F, Bonomo, R.A, Handel, T.M. | Deposit date: | 2006-02-16 | Release date: | 2006-07-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and Computational Characterization of the SHV-1 beta-Lactamase-beta-Lactamase Inhibitor Protein Interface. J.Biol.Chem., 281, 2006
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3C4O
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![BU of 3c4o by Molmil](/molmil-images/mine/3c4o) | Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M/S130K/S146M complex | Descriptor: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein, SULFATE ION | Authors: | Reynolds, K.A, Hanes, M.S, Thomson, J.M, Antczak, A.J, Berger, J.M, Bonomo, R.A, Kirsch, J.F, Handel, T.M. | Deposit date: | 2008-01-30 | Release date: | 2008-05-27 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J.Mol.Biol., 382, 2008
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3C4P
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![BU of 3c4p by Molmil](/molmil-images/mine/3c4p) | Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M complex | Descriptor: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein, SULFATE ION | Authors: | Reynolds, K.A, Hanes, M.S, Thomson, J.M, Antczak, A.J, Berger, J.M, Bonomo, R.A, Kirsch, J.F, Handel, T.M. | Deposit date: | 2008-01-30 | Release date: | 2008-05-27 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J.Mol.Biol., 382, 2008
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6QEL
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![BU of 6qel by Molmil](/molmil-images/mine/6qel) | E. coli DnaBC apo complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA replication protein dnaC, MAGNESIUM ION, ... | Authors: | Arias-Palomo, E, Puri, N, O'Shea Murray, V.L, Yan, Q, Berger, J.M. | Deposit date: | 2019-01-08 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Physical Basis for the Loading of a Bacterial Replicative Helicase onto DNA. Mol.Cell, 74, 2019
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6QEM
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![BU of 6qem by Molmil](/molmil-images/mine/6qem) | E. coli DnaBC complex bound to ssDNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA replication protein DnaC, MAGNESIUM ION, ... | Authors: | Arias-Palomo, E, Puri, N, O'Shea Murray, V.L, Yan, Q, Berger, J.M. | Deposit date: | 2019-01-08 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Physical Basis for the Loading of a Bacterial Replicative Helicase onto DNA. Mol.Cell, 74, 2019
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5HE9
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![BU of 5he9 by Molmil](/molmil-images/mine/5he9) | |
5HE8
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![BU of 5he8 by Molmil](/molmil-images/mine/5he8) | Bacterial initiation protein | Descriptor: | Helicase loader, SULFATE ION | Authors: | Hood, I.V, Berger, J.M. | Deposit date: | 2016-01-05 | Release date: | 2016-06-08 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Bacterial initiation protein To Be Published
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4NMN
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![BU of 4nmn by Molmil](/molmil-images/mine/4nmn) | Aquifex aeolicus replicative helicase (DnaB) complexed with ADP, at 3.3 resolution | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Replicative DNA helicase, ... | Authors: | Lyubimov, A.Y, Strycharska, M.S, Erzberger, J.P, Berger, J.M. | Deposit date: | 2013-11-15 | Release date: | 2014-01-29 | Method: | X-RAY DIFFRACTION (3.301 Å) | Cite: | Nucleotide and partner-protein control of bacterial replicative helicase structure and function. Mol.Cell, 52, 2013
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1L8Q
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![BU of 1l8q by Molmil](/molmil-images/mine/1l8q) | |
1BJT
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![BU of 1bjt by Molmil](/molmil-images/mine/1bjt) | TOPOISOMERASE II RESIDUES 409-1201 | Descriptor: | TOPOISOMERASE II | Authors: | Fass, D, Bogden, C.E, Berger, J.M. | Deposit date: | 1998-06-29 | Release date: | 1999-05-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands. Nat.Struct.Biol., 6, 1999
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4TMA
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![BU of 4tma by Molmil](/molmil-images/mine/4tma) | Crystal structure of gyrase bound to its inhibitor YacG | Descriptor: | DNA gyrase inhibitor YacG, DNA gyrase subunit A, DNA gyrase subunit B, ... | Authors: | Vos, S.M, Lyubimov, A.Y, Hershey, D.M, Schoeffler, A.J, Berger, J.M. | Deposit date: | 2014-05-31 | Release date: | 2014-07-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein. Genes Dev., 28, 2014
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4TXY
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![BU of 4txy by Molmil](/molmil-images/mine/4txy) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog | Descriptor: | Cyclic AMP-GMP synthase, MAGNESIUM ION | Authors: | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | Deposit date: | 2014-07-07 | Release date: | 2014-08-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.0001 Å) | Cite: | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4TY0
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![BU of 4ty0 by Molmil](/molmil-images/mine/4ty0) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG | Descriptor: | ACETATE ION, Cyclic AMP-GMP synthase, MAGNESIUM ION, ... | Authors: | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | Deposit date: | 2014-07-07 | Release date: | 2014-08-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4TXZ
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![BU of 4txz by Molmil](/molmil-images/mine/4txz) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP | Descriptor: | Cyclic AMP-GMP synthase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | Authors: | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | Deposit date: | 2014-07-07 | Release date: | 2014-08-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4KM5
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![BU of 4km5 by Molmil](/molmil-images/mine/4km5) | X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS) | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | Authors: | Kranzusch, P.J, Lee, A.S.Y, Berger, J.M, Doudna, J.A. | Deposit date: | 2013-05-08 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity. Cell Rep, 3, 2013
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