4GFH

Topoisomerase II-DNA-AMPPNP complex

Summary for 4GFH

• Entry DOI: 10.2210/pdb4gfh/pdb
• Related: 1PVG 3L4J 3L4K
• Descriptor: DNA topoisomerase 2, DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ... (7 entities in total)
• Functional Keywords: topoisomerase, protein-dna complex, dna supercoiling, dna replication, atp-binding, dna-binding, isomerase, nucleotide-binding, nucleus, phosphoprotein, isomerase-dna complex, isomerase/dna
• Biological source: Saccharomyces cerevisiae (Baker's yeast)
• Total number of polymer chains: 10
• Total formula weight: 305578.14

Authors

Schmidt, B.H.,Osheroff, N.,Berger, J.M. (deposition date: 2012-08-03, release date: 2012-10-03, Last modification date: 2019-07-31)

• Primary citation: Schmidt, B.H.,Osheroff, N.,Berger, J.M.; Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity.; Nat.Struct.Mol.Biol., 19:1147-1154, 2012; PubMed: 23022727; DOI: 10.1038/nsmb.2388

Experimental method

X-RAY DIFFRACTION (4.408 Å)