Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006259 | biological_process | DNA metabolic process |
A | 0006265 | biological_process | DNA topological change |
F | 0003677 | molecular_function | DNA binding |
F | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
F | 0005524 | molecular_function | ATP binding |
F | 0006259 | biological_process | DNA metabolic process |
F | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG A 1201 |
Chain | Residue |
A | GLU66 |
A | ASN70 |
A | ANP1202 |
site_id | AC2 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE ANP A 1202 |
Chain | Residue |
A | PHE121 |
A | THR126 |
A | SER127 |
A | SER128 |
A | ASN129 |
A | GLY140 |
A | ARG141 |
A | ASN142 |
A | GLY143 |
A | TYR144 |
A | GLY145 |
A | ALA146 |
A | LYS147 |
A | THR195 |
A | GLN365 |
A | LYS367 |
A | MG1201 |
A | ASN70 |
A | ASN74 |
A | ARG77 |
A | ASN99 |
A | ILE104 |
A | ILE120 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG F 1201 |
Chain | Residue |
F | GLU66 |
F | ASN70 |
F | ANP1202 |
site_id | AC4 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE ANP F 1202 |
Chain | Residue |
F | ASN70 |
F | ASN74 |
F | ARG77 |
F | ASN99 |
F | ILE104 |
F | ILE120 |
F | PHE121 |
F | THR126 |
F | SER127 |
F | SER128 |
F | ASN129 |
F | GLY140 |
F | ARG141 |
F | ASN142 |
F | GLY143 |
F | TYR144 |
F | GLY145 |
F | ALA146 |
F | LYS147 |
F | THR195 |
F | GLN365 |
F | LYS367 |
F | MG1201 |
Functional Information from PROSITE/UniProt
site_id | PS00177 |
Number of Residues | 9 |
Details | TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSALS |
Chain | Residue | Details |
A | LEU447-SER455 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | PTR782 | |
F | PTR782 | |
Chain | Residue | Details |
A | ASN70 | |
F | GLN365 | |
A | ASN99 | |
A | SER127 | |
A | GLY140 | |
A | GLN365 | |
F | ASN70 | |
F | ASN99 | |
F | SER127 | |
F | GLY140 | |
Chain | Residue | Details |
A | GLU449 | |
A | ASP526 | |
A | ASP528 | |
F | GLU449 | |
F | ASP526 | |
F | ASP528 | |
Chain | Residue | Details |
A | LYS477 | |
A | TYR734 | |
A | SER740 | |
A | TRP908 | |
F | LYS477 | |
F | TYR734 | |
F | SER740 | |
F | TRP908 | |
Chain | Residue | Details |
A | ASN480 | |
A | ARG650 | |
A | LYS651 | |
A | LYS700 | |
F | ASN480 | |
F | ARG650 | |
F | LYS651 | |
F | LYS700 | |
Chain | Residue | Details |
A | ARG781 | |
F | ARG781 | |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Important for DNA bending; intercalates between base pairs of target DNA => ECO:0000269|PubMed:18097402 |
Chain | Residue | Details |
A | ILE833 | |
F | ILE833 | |
Chain | Residue | Details |
A | THR1086 | |
F | THR1086 | |
Chain | Residue | Details |
A | SER1087 | |
F | SER1087 | |