7MU5

Human DCTPP1 bound to Triptolide

Summary for 7MU5

Entry DOI	10.2210/pdb7mu5/pdb
Descriptor	dCTP pyrophosphatase 1, MAGNESIUM ION, triptolide, ... (4 entities in total)
Functional Keywords	inhibitor, pyrophosphatase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	8
Total formula weight	104520.08
Authors	Hauk, G.,Berger, J.M. (deposition date: 2021-05-14, release date: 2022-08-24, Last modification date: 2023-10-18)
Primary citation	Liu, J.,He, Q.-L.,Zhou, J.,Chikarmane, R.V.,Hauk, G.,Rachakonda, A.,Vaghasia, A.M.,Castagna, N.,Steinberg, R.C.,Anders, N.M.,Wanjiku, T.M.,Nuhn, P.,Shim, J.S.,Giovinazzo, H.,Esopi, D.M.,Kim, K.,Coulter, J.,Wang, R.,Zhou, J.,Rudek, M.A.,Berger, J.M.,Liu, J.O.,Nelson, W.G.,Yegnasubramanian, S. Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance To Be Published,
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation