4O6A
| Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA | Descriptor: | Cyclic GMP-AMP synthase, DNA1, DNA2, ... | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | Deposit date: | 2013-12-20 | Release date: | 2014-02-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.859 Å) | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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3JB6
| In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, RNA-dependent RNA polymerase, VP1 CSP, ... | Authors: | Zhang, X, Ding, K, Yu, X.K, Chang, W, Sun, J.C, Zhou, Z.H. | Deposit date: | 2015-08-02 | Release date: | 2015-10-28 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. Nature, 527, 2015
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3J9D
| Atomic structure of a non-enveloped virus reveals pH sensors for a coordinated process of cell entry | Descriptor: | Outer capsid protein VP2, ZINC ION | Authors: | Zhang, X, Patel, A, Celma, C, Roy, P, Zhou, Z.H. | Deposit date: | 2015-01-09 | Release date: | 2015-12-09 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry. Nat.Struct.Mol.Biol., 23, 2016
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3J9E
| Atomic structure of a non-enveloped virus reveals pH sensors for a coordinated process of cell entry | Descriptor: | VP5 | Authors: | Zhang, X, Patel, A, Celma, C, Roy, P, Zhou, Z.H. | Deposit date: | 2015-01-10 | Release date: | 2015-12-09 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry. Nat.Struct.Mol.Biol., 23, 2016
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3JB7
| In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus | Descriptor: | CPV RNA-dependent RNA polymerase, CYTIDINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhang, X, Ding, K, Yu, X.K, Chang, W, Sun, J.C, Zhou, Z.H. | Deposit date: | 2015-08-03 | Release date: | 2015-10-28 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (4.001 Å) | Cite: | In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. Nature, 527, 2015
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3F4M
| Crystal structure of TIPE2 | Descriptor: | CHLORIDE ION, Tumor necrosis factor, alpha-induced protein 8-like protein 2 | Authors: | Zhang, X, Wang, J, Shi, Y. | Deposit date: | 2008-11-01 | Release date: | 2009-03-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.696 Å) | Cite: | Crystal structure of TIPE2 provides insights into immune homeostasis Nat.Struct.Mol.Biol., 16, 2009
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5V57
| 3.0A SYN structure of the multi-domain human smoothened receptor in complex with TC114 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ... | Authors: | Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F. | Deposit date: | 2017-03-13 | Release date: | 2017-05-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun, 8, 2017
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5V56
| 2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ... | Authors: | Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F. | Deposit date: | 2017-03-13 | Release date: | 2017-05-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun, 8, 2017
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5XBM
| Structure of SCARB2-JL2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosome membrane protein 2, ... | Authors: | Zhang, X, Yang, P, Wang, N, Zhang, J, Li, J, Guo, H, Yin, X, Rao, Z, Wang, X, Zhang, L. | Deposit date: | 2017-03-20 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.501 Å) | Cite: | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein Cell, 8, 2017
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4JDL
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5TEC
| Crystal structure of the TIR domain from the Arabidopsis thaliana NLR protein SNC1 | Descriptor: | Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 | Authors: | Zhang, X, Bentham, A, Ve, T, Williams, S.J, Kobe, B. | Deposit date: | 2016-09-20 | Release date: | 2017-02-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Multiple functional self-association interfaces in plant TIR domains. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2GS6
| Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate | Descriptor: | CHLORIDE ION, Epidermal growth factor receptor, Peptide, ... | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | Deposit date: | 2006-04-25 | Release date: | 2006-06-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor Cell(Cambridge,Mass.), 125, 2006
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2GS7
| Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP | Descriptor: | Epidermal growth factor receptor, IODIDE ION, MAGNESIUM ION, ... | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | Deposit date: | 2006-04-25 | Release date: | 2006-06-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor Cell(Cambridge,Mass.), 125, 2006
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2GS2
| Crystal Structure of the active EGFR kinase domain | Descriptor: | Epidermal growth factor receptor | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | Deposit date: | 2006-04-25 | Release date: | 2006-06-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell(Cambridge,Mass.), 125, 2006
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5VJJ
| Crystal structure of the flax-rust effector AvrP | Descriptor: | Avirulence protein AvrP123, ZINC ION | Authors: | Zhang, X, Ericsson, D.J, Williams, S.J, Kobe, B. | Deposit date: | 2017-04-19 | Release date: | 2017-08-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P. Mol. Plant Pathol., 19, 2018
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4JDA
| Complex structure of abscisic acid receptor PYL3 with (-)-ABA | Descriptor: | (2Z,4E)-5-[(1R)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3 | Authors: | Zhang, X, Wang, G, Chen, Z. | Deposit date: | 2013-02-24 | Release date: | 2013-07-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR Plos One, 8, 2013
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2MX6
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8HMZ
| Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex | Descriptor: | Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ... | Authors: | Zhang, X, Yang, F, Zhan, X, Shi, Y. | Deposit date: | 2022-12-06 | Release date: | 2023-04-19 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease. Mol.Cell, 83, 2023
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8HMY
| Cryo-EM structure of the human pre-catalytic TSEN/pre-tRNA complex | Descriptor: | Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ... | Authors: | Zhang, X, Yang, F, Zhan, X, Shi, Y. | Deposit date: | 2022-12-06 | Release date: | 2023-04-19 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease. Mol.Cell, 83, 2023
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2P0Q
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2P0P
| Calcium binding protein in the free form | Descriptor: | Alr1010 protein | Authors: | Zhang, X, Hu, Y, Jin, C. | Deposit date: | 2007-02-28 | Release date: | 2008-03-25 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Solution Structures of Ccbp from Anabaena Reveals a New Fold and Novel Calcium Binding Sites To be Published
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2RFD
| Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor, SULFATE ION | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | Deposit date: | 2007-09-28 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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2RF9
| Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | Deposit date: | 2007-09-28 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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2RFE
| Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | Deposit date: | 2007-09-28 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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5ZMD
| Crystal structure of FTO in complex with m6dA modified ssDNA | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase FTO, DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3'), MANGANESE (II) ION, ... | Authors: | Zhang, X, Wei, L.H, Luo, J, Xiao, Y, Liu, J, Zhang, W, Zhang, L, Jia, G.F. | Deposit date: | 2018-04-02 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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