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4X90
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BU of 4x90 by Molmil
Crystal structure of Lysosomal Phospholipase A2
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Glukhova, A, Tesmer, J.J.G.
登録日2014-12-11
公開日2015-03-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4WNK
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BU of 4wnk by Molmil
Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022
分子名称: (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, G protein-coupled receptor kinase 5, SULFATE ION
著者Homan, K.T, Tesmer, J.J.G.
登録日2014-10-13
公開日2015-06-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.
J.Biol.Chem., 290, 2015
4X91
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Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Glukhova, A, Tesmer, J.J.G.
登録日2014-12-11
公開日2015-03-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X93
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BU of 4x93 by Molmil
Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (tetragonal form)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Glukhova, A, Tesmer, J.J.G.
登録日2014-12-11
公開日2015-03-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X92
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Crystal structure of Lysosomal Phospholipase A2-S165A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Group XV phospholipase A2
著者Glukhova, A, Tesmer, J.J.G.
登録日2014-12-11
公開日2015-03-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X96
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Low resolution crystal structure of Lecithin:Cholesterol Acyltransferase (LCAT; residues 21-397)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Phosphatidylcholine-sterol acyltransferase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Glukhova, A, Tesmer, J.J.G.
登録日2014-12-11
公開日2015-03-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (8.69 Å)
主引用文献Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X95
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Crystal structure of fully glycosylated Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Group XV phospholipase A2, METHYL ARACHIDONYL FLUOROPHOSPHONATE, ...
著者Glukhova, A, Tesmer, J.J.G.
登録日2014-12-11
公開日2015-03-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X97
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BU of 4x97 by Molmil
Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
著者Glukhova, A, Tesmer, J.J.G.
登録日2014-12-11
公開日2015-03-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
3PUI
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BU of 3pui by Molmil
Cocaine Esterase with mutations G4C, S10C
分子名称: CHLORIDE ION, Cocaine esterase, SODIUM ION
著者Nance, M.R, Tesmer, J.J.G.
登録日2010-12-04
公開日2011-09-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3PUH
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BU of 3puh by Molmil
Cocaine Esterase, wild-type biologically active dimer
分子名称: Cocaine esterase, GLYCEROL, SULFATE ION
著者Nance, M.R, Tesmer, J.J.G.
登録日2010-12-04
公開日2011-09-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3QC9
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BU of 3qc9 by Molmil
Crystal structure of cross-linked bovine GRK1 T8C/N480C double mutant complexed with ADP and Mg
分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
著者Huang, C.-C, Tesmer, J.J.G.
登録日2011-01-15
公開日2011-02-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain.
Biochemistry, 50, 2011
6D8Z
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BU of 6d8z by Molmil
Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio
分子名称: Triple functional domain protein
著者Bandekar, S, Tesmer, J.J.
登録日2018-04-27
公開日2019-02-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.
Sci Signal, 12, 2019
1BAP
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BU of 1bap by Molmil
A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
分子名称: L-ARABINOSE-BINDING PROTEIN, alpha-L-arabinopyranose, beta-L-arabinopyranose
著者Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
登録日1991-11-15
公開日1992-01-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
1AZT
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BU of 1azt by Molmil
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, MAGNESIUM ION, ...
著者Tesmer, J.J.G, Sprang, S.R.
登録日1997-11-20
公開日1998-02-25
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
1APB
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BU of 1apb by Molmil
A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
分子名称: L-ARABINOSE-BINDING PROTEIN, alpha-D-fucopyranose, beta-D-fucopyranose
著者Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
登録日1991-11-15
公開日1992-01-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
5UKM
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BU of 5ukm by Molmil
bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as)
分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(1H-pyrazol-5-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cruz-Rodriguez, O, Tesmer, J.J.G.
登録日2017-01-23
公開日2017-04-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
5UKK
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Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak)
分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(pyridin-2-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cato, M.C, Homan, K.T, Tesmer, J.J.G.
登録日2017-01-23
公開日2017-04-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
5UKL
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Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)
分子名称: 2-{5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-N-[2-(1H-pyrazol-4-yl)ethyl]acetamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cato, M.C, Homan, K.T, Tesmer, J.J.G.
登録日2017-01-23
公開日2017-04-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
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