6KBE
| Structure of Deubiquitinase | Descriptor: | Polyubiquitin-C, Ubiquitin thioesterase | Authors: | Lu, L.N, Liu, L, Wang, F. | Deposit date: | 2019-06-24 | Release date: | 2020-06-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.339 Å) | Cite: | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains Nat Commun, 13, 2022
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6K9P
| Structure of Deubiquitinase | Descriptor: | Ubiquitin, Ubiquitin thioesterase | Authors: | Lu, L.N, Liu, L, Wang, F. | Deposit date: | 2019-06-17 | Release date: | 2020-06-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.047 Å) | Cite: | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains Nat Commun, 13, 2022
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8UCD
| Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, AMG 509 anti-STEAP1 Fab, heavy chain, ... | Authors: | Li, F, Bailis, J.M, Zhang, H. | Deposit date: | 2023-09-26 | Release date: | 2023-11-22 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer. Cancer Discov, 14, 2024
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8HR1
| Cryo-EM structure of SSX1 bound to the unmodified nucleosome at a resolution of 3.02 angstrom | Descriptor: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | Authors: | Zebin, T, Ai, H.S, Ziyu, X, Man, P, Liu, L. | Deposit date: | 2022-12-14 | Release date: | 2023-09-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
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8HQY
| Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom | Descriptor: | DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... | Authors: | Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. | Deposit date: | 2022-12-14 | Release date: | 2023-09-27 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
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3G6L
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3G6M
| crystal structure of a chitinase CrChi1 from the nematophagous fungus Clonostachys rosea in complex with a potent inhibitor caffeine | Descriptor: | CAFFEINE, Chitinase | Authors: | Gan, Z, Yang, J, Lou, Z, Rao, Z, Zhang, K.-Q. | Deposit date: | 2009-02-06 | Release date: | 2010-02-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure and mutagenesis analysis of chitinase CrChi1 from the nematophagous fungus Clonostachys rosea in complex with the inhibitor caffeine Microbiology, 156, 2010
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6ISU
| Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein UCHL3 | Descriptor: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L3 | Authors: | Ding, S, Pan, M, Zheng, Q, Ren, Y, Hong, D. | Deposit date: | 2018-11-19 | Release date: | 2019-02-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.866 Å) | Cite: | Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains. Angew. Chem. Int. Ed. Engl., 58, 2019
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6K6L
| YGL082W-catalytic domain | Descriptor: | pseudo deubiquitinase | Authors: | Lu, L.N, Wang, F. | Deposit date: | 2019-06-03 | Release date: | 2019-07-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop Sci China Chem, 2019
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7T3H
| MicroED structure of Dynobactin | Descriptor: | TRP-ASN-SER-ASN-VAL-HIS-SER-TYR-ARG-PHE | Authors: | Yoo, B.-K, Kaiser, J.T, Rees, D.C, Miller, R.D, Iinishi, A, Lewis, K, Bowman, S. | Deposit date: | 2021-12-07 | Release date: | 2022-10-19 | Method: | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | Cite: | Computational identification of a systemic antibiotic for gram-negative bacteria. Nat Microbiol, 7, 2022
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7UGW
| M. tuberculosis DNA gyrase cleavage core bound to DNA and evybactin | Descriptor: | DNA (46-MER), DNA gyrase subunit A, DNA gyrase subunit B, ... | Authors: | Hauk, G, Imai, Y, Lewis, K, Berger, J.M. | Deposit date: | 2022-03-25 | Release date: | 2022-08-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis. Nat.Chem.Biol., 18, 2022
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2RI5
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2RHU
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2RI7
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2RI2
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2RHI
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2RHY
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2RHX
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2RI3
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2RHZ
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7XD1
| cryo-EM structure of unmodified nucleosome | Descriptor: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | Authors: | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | Deposit date: | 2022-03-26 | Release date: | 2022-04-20 | Last modified: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
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7XCR
| Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | Authors: | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | Deposit date: | 2022-03-25 | Release date: | 2022-04-20 | Last modified: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
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7XD0
| cryo-EM structure of H2BK34ub nucleosome | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | Authors: | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | Deposit date: | 2022-03-26 | Release date: | 2022-04-20 | Last modified: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
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7XCT
| Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B type 1-K, ... | Authors: | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | Deposit date: | 2022-03-25 | Release date: | 2022-04-20 | Last modified: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
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7YWA
| Structure of DinI in complex with RecA filament | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), DNA damage-inducible protein I, MAGNESIUM ION, ... | Authors: | Gao, B, Feng, Y. | Deposit date: | 2022-08-22 | Release date: | 2022-12-21 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structural basis for regulation of SOS response in bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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