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9PAI
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CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1
分子名称: PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 19-364, PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 365-397
著者Aertgeerts, K, De Bondt, H.L, De Ranter, C.J, Declerck, P.J.
登録日1999-03-11
公開日1999-03-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1.
Nat.Struct.Biol., 2, 1995
6ZRV
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Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93)
分子名称: Plasminogen activator inhibitor 1, VHH-s-a93 (Nb93)
著者Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2020-07-15
公開日2020-08-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.
Int J Mol Sci, 21, 2020
3EOX
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High quality structure of cleaved PAI-1-stab
分子名称: Plasminogen activator inhibitor 1
著者Dewilde, M, Declerck, P.J, Rabijns, A, Strelkov, S.V.
登録日2008-09-29
公開日2009-02-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献High quality structure of cleaved PAI-1-stab.
J.Struct.Biol., 165, 2009
7AQF
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Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab)
分子名称: 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid, Plasminogen activator inhibitor 1
著者Sillen, M, Strelkov, S.V, Declerck, P.J.
登録日2020-10-21
公開日2021-02-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.
Int J Mol Sci, 22, 2021
7AQG
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Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F)
分子名称: 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid, Plasminogen activator inhibitor 1, VHH-2g-42 (Nb42), ...
著者Sillen, M, Strelkov, S.V, Declerck, P.J.
登録日2020-10-21
公開日2021-02-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.
Int J Mol Sci, 22, 2021
7AQL
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Crystal Structure of an Anti-Plasminogen Activator Inhibitor-1 (PAI-1) scFv antibody fragment (scFv-33H1F7)
分子名称: SULFATE ION, scFv-33H1F7
著者Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2020-10-22
公開日2021-11-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of an Anti-Plasminogen Activator Inhibitor-1 (PAI-1) scFv antibody fragment (scFv-33H1F7)
To Be Published
3LW2
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Mouse Plasminogen Activator Inhibitor-1 (PAI-1)
分子名称: Plasminogen activator inhibitor 1
著者Dewilde, M, Van De Craen, B, Compernolle, G, Madsen, J.B, Strelkov, S.V, Gils, A, Declerck, P.J.
登録日2010-02-23
公開日2010-04-07
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.
J.Struct.Biol., 171, 2010
5LHR
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The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22
分子名称: Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHP
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The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
分子名称: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ...
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHQ
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The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
分子名称: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHS
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The ligand free catalytic domain of murine urokinase-type plasminogen activator
分子名称: NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.047 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
6GWQ
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BU of 6gwq by Molmil
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42)
分子名称: Plasminogen Activator Inhibitor-1, VHH-2g-42
著者Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2018-06-25
公開日2020-01-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
6GWP
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Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
分子名称: Plasminogen Activator Inhibitor-1, VHH-2g-42, VHH-2w-64
著者Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2018-06-25
公開日2020-01-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
6GWN
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Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
分子名称: Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64
著者Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2018-06-25
公開日2020-01-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
5HVF
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Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Carboxypeptidase B2, ...
著者Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2016-01-28
公開日2016-06-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVG
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Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
著者Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2016-01-28
公開日2016-06-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVH
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Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase B2, ...
著者Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
登録日2016-01-28
公開日2016-06-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
1DB2
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BU of 1db2 by Molmil
CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1
分子名称: PLASMINOGEN ACTIVATOR INHIBITOR-1
著者Nar, H, Bauer, M, Stassen, J.M, Lang, D, Gils, A, Declerck, P.
登録日1999-11-02
公開日1999-11-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
J.Mol.Biol., 297, 2000
5LHN
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The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
分子名称: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ...
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5HGG
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Crystal structure of uPA in complex with a camelid-derived antibody fragment
分子名称: (3S)-3-[(2S,3S,4R)-3,4-DIMETHYLTETRAHYDROFURAN-2-YL]BUTYL LAURATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Camelid Derived Antibody Fragment, ...
著者Yung, K.W.Y, Kromann-Hansen, T, Andreasen, P.A, Ngo, J.C.K.
登録日2016-01-08
公開日2016-06-01
最終更新日2016-08-10
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior
J.Biol.Chem., 291, 2016
5HDO
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Crystal structure of a nanobody raised against urokinase-type plasminogen activator
分子名称: Anti-HCV NS3/4A serine protease immoglobulin heavy chain, CHLORIDE ION, SULFATE ION
著者Kromann-Hansen, T.
登録日2016-01-05
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior.
J.Biol.Chem., 291, 2016

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