8HX3
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8JT6
| 5-HT1A-Gi in complex with compound (R)-IHCH-7179 | Descriptor: | 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Chen, Z, Xu, P, Huang, S, Xu, H.E, Wang, S. | Deposit date: | 2023-06-21 | Release date: | 2024-02-28 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 2024
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8JT8
| Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | Authors: | Chen, Z, Fan, L, Wang, S. | Deposit date: | 2023-06-21 | Release date: | 2024-02-28 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 2024
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6AZE
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6HRL
| Crystal structure of the Kelch domain of human KLHL17 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Kelch-like protein 17, ... | Authors: | Chen, Z, Williams, E, Sorrell, F.J, Newman, J.A, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, F, Edwards, C.H, Bountra, C, Bullock, A.N. | Deposit date: | 2018-09-27 | Release date: | 2018-10-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the Kelch domain of human KLHL17 To Be Published
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7YAG
| CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 1 | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Chen, Z, Watanabe, S, Inaba, K. | Deposit date: | 2022-06-28 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus. Sci Adv, 9, 2023
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7YAI
| CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 3 | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, Nanobody head piece of megabody, ... | Authors: | Chen, Z, Watanabe, S, Inaba, K. | Deposit date: | 2022-06-28 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus. Sci Adv, 9, 2023
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7YAM
| CryoEM structure of SPCA1a in E2P state | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION | Authors: | Chen, Z, Watanabe, S, Inaba, K. | Deposit date: | 2022-06-28 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus. Sci Adv, 9, 2023
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7YAH
| CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 2 | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Chen, Z, Watanabe, S, Inaba, K. | Deposit date: | 2022-06-28 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus. Sci Adv, 9, 2023
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7YAJ
| CryoEM structure of SPCA1a in E1-Mn-AMPPCP state subclass 1 | Descriptor: | Calcium-transporting ATPase type 2C member 1, MANGANESE (II) ION, Nanobody head piece of megabody, ... | Authors: | Chen, Z, Watanabe, S, Inaba, K. | Deposit date: | 2022-06-28 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus. Sci Adv, 9, 2023
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5JXR
| Crystal structure of MtISWI | Descriptor: | CHLORIDE ION, Chromatin-remodeling complex ATPase-like protein | Authors: | Chen, Z, Yan, L. | Deposit date: | 2016-05-13 | Release date: | 2016-12-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.404 Å) | Cite: | Structure and regulation of the chromatin remodeller ISWI Nature, 540, 2016
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5KU6
| Crystal structure for the complex of human carbonic anhydrase IV and methazolamide | Descriptor: | ACETATE ION, Carbonic anhydrase 4, GLYCEROL, ... | Authors: | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | Deposit date: | 2016-07-12 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47, 2018
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6EGC
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4XOH
| Mechanistic insights into anchorage of the contractile ring from yeast to humans | Descriptor: | Division mal foutue 1 protein | Authors: | Chen, Z, Wu, J.-Q, Wang, J, Guan, R, Sun, L, Lee, I.-J, Liu, Y, Chen, M. | Deposit date: | 2015-01-16 | Release date: | 2015-07-15 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell, 33, 2015
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5IXY
| Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one | Descriptor: | (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Chen, Z, Eigenbrot, C. | Deposit date: | 2016-03-23 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
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8SYM
| Human VPS29/VPS35L Complex (Locally refined map) | Descriptor: | VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 29 | Authors: | Chen, Z, Chen, B, Burstein, E, Han, Y. | Deposit date: | 2023-05-25 | Release date: | 2023-11-01 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural organization of the retriever-CCC endosomal recycling complex. Nat.Struct.Mol.Biol., 2023
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8SYN
| Human VPS35L/VPS29/VPS26C Complex | Descriptor: | VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 26C, Vacuolar protein sorting-associated protein 29 | Authors: | Chen, Z, Chen, B, Burstein, E, Han, Y. | Deposit date: | 2023-05-25 | Release date: | 2023-11-01 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural organization of the retriever-CCC endosomal recycling complex. Nat.Struct.Mol.Biol., 2023
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8SYO
| Human Retriever VPS35L/VPS29/VPS26C Complex (Composite Map) | Descriptor: | VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 26C, Vacuolar protein sorting-associated protein 29 | Authors: | Chen, Z, Chen, B, Burstein, E, Han, Y. | Deposit date: | 2023-05-25 | Release date: | 2023-11-01 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural organization of the retriever-CCC endosomal recycling complex. Nat.Struct.Mol.Biol., 2023
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1IAP
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4AKQ
| Mutations in the neighbourhood of CotA-laccase trinuclear site: E498D mutant | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | Authors: | Silva, C.S, Chen, Z, Durao, P, Pereira, M.M, Todorovic, S, Hildebrandt, P, Martins, L.O, Lindley, P.F, Bento, I. | Deposit date: | 2012-02-28 | Release date: | 2012-03-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Role of Glu498 in the Dioxygen Reactivity of Cota-Laccase from Bacillus Subtilis. Dalton Trans, 39, 2010
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4AKP
| Mutations in the neighbourhood of CotA-laccase trinuclear site: E498T mutant | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | Authors: | Silva, C.S, Chen, Z, Durao, P, Pereira, M.M, Todorovic, S, Hildebrandt, P, Martins, L.O, Lindley, P.F, Bento, I. | Deposit date: | 2012-02-28 | Release date: | 2012-03-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Role of Glu498 in the Dioxygen Reactivity of Cota-Laccase from Bacillus Subtilis. Dalton Trans, 39, 2010
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4AKO
| Mutations in the neighbourhood of CotA-laccase trinuclear site: E498L mutant | Descriptor: | 1,2-ETHANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | Authors: | Silva, C.S, Chen, Z, Durao, P, Pereira, M.M, Todorovic, S, Hildebrandt, P, Martins, L.O, Lindley, P.F, Bento, I. | Deposit date: | 2012-02-28 | Release date: | 2012-03-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Role of Glu498 in the Dioxygen Reactivity of Cota-Laccase from Bacillus Subtilis. Dalton Trans, 39, 2010
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2KAI
| REFINED 2.5 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BY PORCINE KALLIKREIN A AND THE BOVINE PANCREATIC TRYPSIN INHIBITOR. CRYSTALLIZATION, PATTERSON SEARCH, STRUCTURE DETERMINATION, REFINEMENT, STRUCTURE AND COMPARISON WITH ITS COMPONENTS AND WITH THE BOVINE TRYPSIN-PANCREATIC TRYPSIN INHIBITOR COMPLEX | Descriptor: | BOVINE PANCREATIC TRYPSIN INHIBITOR, KALLIKREIN A | Authors: | Bode, W, Chen, Z. | Deposit date: | 1984-05-21 | Release date: | 1984-07-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Refined 2.5 A X-ray crystal structure of the complex formed by porcine kallikrein A and the bovine pancreatic trypsin inhibitor. Crystallization, Patterson search, structure determination, refinement, structure and comparison with its components and with the bovine trypsin-pancreatic trypsin inhibitor complex J.Mol.Biol., 164, 1983
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2M01
| Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom | Descriptor: | Protease inhibitor LmKTT-1a | Authors: | Luo, F, Jiang, L, Liu, M, Chen, Z, Wu, Y. | Deposit date: | 2012-10-15 | Release date: | 2013-11-13 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. Plos One, 8, 2013
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6DLM
| DHD127 | Descriptor: | DHD127_A, DHD127_B | Authors: | Bick, M.J, Chen, Z, Baker, D. | Deposit date: | 2018-06-01 | Release date: | 2018-12-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.753 Å) | Cite: | Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
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