6AZE

Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog

Summary for 6AZE

• Entry DOI: 10.2210/pdb6aze/pdb
• Related: 2F6J
• Descriptor: Nucleosome-remodeling factor subunit BPTF, ALA-ARG-THR-ML3-GLN-THR, ZINC ION, ... (4 entities in total)
• Functional Keywords: phd-finger, bromodomain, histone reader, methyllsine analog, mla, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 20596.17

Authors

Chen, Z.,Ruthenburg, A.J. (deposition date: 2017-09-11, release date: 2018-09-19, Last modification date: 2020-01-01)

• Primary citation: Chen, Z.,Ruthenburg, A.J.,Notti, R.Q.,Ueberheide, B.,Banaszynski, L.A.; Quantitative and structural assessment of methyllysine analog engagement by cognate binding proteins reveals decrements that can impact qualitative experiment interpretation; To be published,

Experimental method

X-RAY DIFFRACTION (2.451 Å)