6AZE

Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016589	cellular_component	NURF complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 201

Chain	Residue
A	CYS11
A	CYS13
A	HIS34
A	CYS37

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 202

Chain	Residue
A	CYS26
A	CYS29
A	CYS53
A	CYS56

---

site_id	AC3
Number of Residues	9
Details	binding site for Ligand residues ML3 P 4 through GLN P 5 bound to THR P 3

Chain	Residue
A	TYR17
A	LYS21
A	PHE22
A	TYR23
A	TRP32
A	HOH306
P	THR3
P	THR6
A	TYR10

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. AwpFlepvDpndap..DYYgvIkepMdlatMeervqrry..Yekltefvadmtk.IfdNCryY

Chain	Residue	Details
A	ALA90-TYR147

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CiCktPYdeskfyigC

Chain	Residue	Details
A	CYS11-CYS26

---

site_id	PS01359
Number of Residues	46
Details	ZF_PHD_1 Zinc finger PHD-type signature. Ci.Cktpydeskfy...................................IgCdr..Cqnw.YHgrCvgilqseaelide................................YvCpqC

Chain	Residue	Details
A	CYS11-CYS56

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	104
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	51
Details	Zinc finger: {"description":"PHD-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Histone H3K4me3 binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---